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|Title:||Effects of perhexiline on myocardial deformation in patients with ischaemic left ventricular dysfunction|
|Citation:||International Journal of Cardiology, 2010; 139(2):107-112|
|Publisher:||Elsevier Sci Ireland Ltd|
|Manish Bansal, Jonathan Chan, Rodel Leano, Peter Pillans, John Horowitz, Thomas H. Marwick|
|Abstract:||Background: Perhexiline improves functional capacity in heart failure, but the mechanisms are undefined. We sought its effects on myocardial deformation in patients with viable myocardium. Methods: Thirty-six medically-treated patients, stable at least 6 months post-infarction with LV dysfunction and myocardial viability shown by dobutamine echo (DbE) were randomised to receive perhexiline or matching placebo for 1 year. Cardiopulmonary exercise testing and DbE were performed at baseline and follow-up. Peak-systolic strain (S) and strain rate (SR) were measured offline in 111 dysfunctional segments in the placebo and 88 in the treatment group at rest, low-dose (LDD) and peak-dose dobutamine (PDD). Results: The serum perhexiline level was 0.27±0.7 µg/l. There was no difference in the wall motion response to dobutamine at baseline and follow-up. Resting strain and SR were similar in the two groups at baseline and follow-up. However, SR at LDD and PDD increased in the placebo group and worsened during the same period in the perhexiline group. Patients on perhexiline and placebo had a similar rate-pressure product and exercise duration at baseline (7.9±2.7 vs 8.7±3.3 min, p=NS) and follow-up (9.6±4.6 vs 10.1±3.03 min, p=NS). Conclusion: Perhexiline does not improve the deformation of abnormal myocardial segments in patients with ischaemic LV dysfunction.|
|Keywords:||Myocardial viability; Heart failure; Coronary artery disease; Myocardial infarction; Strain imaging|
|Rights:||© 2009 Published by Elsevier Ireland Ltd.|
|Appears in Collections:||Medicine publications|
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