Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/61110
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Type: | Journal article |
Title: | Local and systemic biomarkers in gingival crevicular fluid increase odds of periodontitis |
Author: | Fitzsimmons, T. Sanders, A. Bartold, P. Slade, G. |
Citation: | Journal of Clinical Periodontology, 2010; 37(1):30-36 |
Publisher: | Blackwell Munksgaard |
Issue Date: | 2010 |
ISSN: | 0303-6979 1600-051X |
Statement of Responsibility: | Tracy R. Fitzsimmons, Anne E. Sanders, P. Mark Bartold and Gary D. Slade |
Abstract: | <h4>Aim</h4>To determine the independent and combined associations of interleukin-1beta (IL-1beta) and C-reactive protein (CRP) in gingival crevicular fluid (GCF) on periodontitis case status in the Australian population.<h4>Materials and methods</h4>GCF was collected from 939 subjects selected from the 2004-2006 Australian National Survey of Adult Oral Health: 430 cases had examiner-diagnosed periodontitis, and 509 controls did not. IL-1beta and CRP in GCF were detected by enzyme-linked immunosorbent assays. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated in bivariate and stratified analysis and fully adjusted ORs were estimated using multivariate logistic regression.<h4>Results</h4>Greater odds of having periodontitis was associated with higher amounts of IL-1beta (OR=2.4, 95% CI=1.7-3.4 for highest tertile of IL-1beta relative to lowest tertile) and CRP (OR=1.9, 95% CI=1.5-2.5 for detectable CRP relative to undetectable CRP). In stratified analysis, there was no significant interaction between biomarkers (p=0.68). In the multivariate analyses that controlled for conventional periodontal risk factors, these relationships remained (IL-1beta OR=1.8, 95% CI=1.1-2.6; CRP OR=1.7, 95% CI=1.3-2.3).<h4>Conclusions</h4>Elevated odds of clinical periodontitis was associated independently with each biomarker. This suggests that people with elevated biomarkers indicative of either local (IL-1beta) or systemic (CRP) inflammation are more likely to suffer from periodontal disease. |
Keywords: | C-reactive protein gingival crevicular fluid interleukin-1β periodontitis |
Rights: | © 2009 University of Adelaide |
DOI: | 10.1111/j.1600-051X.2009.01506.x |
Published version: | http://dx.doi.org/10.1111/j.1600-051x.2009.01506.x |
Appears in Collections: | Aurora harvest Dentistry publications |
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