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dc.contributor.authorBuchanan, M.en
dc.contributor.authorHutchinson, M.en
dc.contributor.authorWatkins, L.en
dc.contributor.authorYin, H.en
dc.identifier.citationJournal of Neurochemistry, 2010; 114(1):13-27en
dc.description.abstractThe responses of the brain to infection, ischemia and trauma share remarkable similarities. These and other conditions of the CNS coordinate an innate immune response marked by activation of microglia, the macrophage-like cells of the nervous system. An important contributor to microglial activation is toll-like receptor 4, a pathogen-associated molecular pattern receptor known to initiate an inflammatory cascade in response to various CNS stimuli. The present review traces new efforts to characterize and control toll-like receptor 4 in inflammatory etiologies of the nervous system.en
dc.description.statementofresponsibilityMadison M. Buchanan, Mark Hutchinson, Linda R. Watkins and Hang Yinen
dc.publisherBlackwell Publishing Ltden
dc.rights© 2010 The Authors. Journal Compilation © 2010 International Society for Neurochemistryen
dc.subjectendogenous ligand; glia; MD2; neuroinflammation; Toll-like receptor; sepsisen
dc.titleToll-like receptor 4 in CNS pathologiesen
dc.typeJournal articleen
dc.contributor.departmentClinical and Experimental Pharmacologyen
pubs.library.collectionPharmacology publicationsen
dc.identifier.orcidHutchinson, M. [0000-0003-2154-5950]en
Appears in Collections:Pharmacology publications

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