Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/61821
Citations
Scopus Web of ScienceĀ® Altmetric
?
?
Type: Journal article
Title: Placental programming of postnatal diabetes and impaired insulin action after IUGR
Author: Gatford, K.
Simmons, R.
De Blasio, M.
Robinson, J.
Owens, J.
Citation: Placenta, 2010; 31(SUPPL.):S60-S65
Publisher: W B Saunders Co Ltd
Issue Date: 2010
ISSN: 0143-4004
1532-3102
Statement of
Responsibility: 
K.L. Gatford, R.A. Simmons, M.J. De Blasio, J.S. Robinson and J.A. Owens
Abstract: Being born small due to poor growth before birth increases the risk of developing metabolic disease, including type 2 diabetes, in later life. Inadequate insulin secretion and decreasing insulin sensitivity contribute to this increased diabetes risk. Impaired placental growth, development and function are major causes of impaired fetal growth and development and therefore of IUGR. Restricted placental growth (PR) and function in non-human animals induces similar changes in insulin secretion and sensitivity as in human IUGR, making these valuable tools to investigate the underlying mechanisms and to test interventions to prevent or ameliorate the risk of disease after IUGR. Epigenetic changes induced by an adverse fetal environment are strongly implicated as causes of later impaired insulin action. These have been well-characterised in the PR rat, where impaired insulin secretion is linked to epigenetic changes at the Pdx-1 promotor and reduced expression of this transcription factor. Present research is particularly focussed on developing intervention strategies to prevent or reverse epigenetic changes, and normalise gene expression and insulin action after PR, in order to translate this to treatments to improve outcomes in human IUGR.
Keywords: IUGR; Placental restriction; Diabetes; Epigenetics; Interventions
Rights: Copyright 2010 Published by IFPA and Elsevier Ltd.
RMID: 0020100145
DOI: 10.1016/j.placenta.2009.12.015
Appears in Collections:Obstetrics and Gynaecology publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.