Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/61987
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Type: Journal article
Title: Experimental colonization of the canine urinary tract with the asymptomatic bacteriuria Escherichia coli strain 83972
Author: Thompson, M.
Totsika, M.
Schembri, M.
Mills, P.
Seton, E.
Trott, D.
Citation: Veterinary Microbiology, 2011; 147(1-2):205-208
Publisher: Elsevier Science BV
Issue Date: 2011
ISSN: 0378-1135
1873-2542
Statement of
Responsibility: 
Mary F. Thompson, Makrina Totsika, Mark A. Schembri, Paul C. Mills, Erica J. Seton, Darren J. Trott
Abstract: Establishment of asymptomatic bacteriuria (ABU) with Escherichia coli 83972 is a viable prophylactic alternative to antibiotic therapy for the prevention of recurrent bacterial urinary tract infection in humans. Approximately 2 × 10(8) viable E. coli 83972 cells were introduced into the bladder of six healthy female dogs via a sterile urinary catheter. The presence of pyuria, depression, stranguria, pollakiuria and haematuria was documented for 6 weeks and urinalysis and aerobic bacterial cultures were performed every 24-72 h. Pyuria was present in all dogs on day 1 post-inoculation and 4/6 dogs (67%) had a positive urine culture on this day. Duration of colonization ranged from 0 to 10 days (median 4 days). Four dogs were re-inoculated on day 20. Duration of colonization following the second inoculation ranged from 1 to 3 days. No dog suffered pyrexia or appeared systemically unwell but all dogs initially exhibited mild pollakiuria and a small number displayed gross haematuria and/or stranguria. By day 3 of each trial all clinical signs had resolved. Persistent bacteriuria was not achieved in any dog but two dogs were colonized for 10 days following a single inoculation. Further research is required to determine whether establishment of ABU in dogs with recurrent urinary tract infection is a viable alternative to repeated doses of antimicrobial agents.
Keywords: Urinary tract infection; Bacteriuria; Canine; Bacterial interference; Colonization
Rights: Crown copyright © 2010 Published by Elsevier B.V.
RMID: 0020100397
DOI: 10.1016/j.vetmic.2010.06.007
Appears in Collections:Animal and Veterinary Sciences publications

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