Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/62056
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Type: Journal article
Title: Dual roles for macrophages in ovarian cycle-associated development and remodelling of the mammary gland epithelium
Author: Chua, C.
Hodson, L.
Moldenhauer, L.
Robertson, S.
Ingman, W.
Citation: Development, 2010; 137(24):4229-4238
Publisher: Company of Biologists Ltd
Issue Date: 2010
ISSN: 0950-1991
1477-9129
Statement of
Responsibility: 
Angela C. L. Chua, Leigh J. Hodson, Lachlan M. Moldenhauer, Sarah A. Robertson and Wendy V. Ingman
Abstract: Each ovarian cycle, the mammary gland epithelium rotates through a sequence of hormonally regulated cell proliferation, differentiation and apoptosis. These studies investigate the role of macrophages in this cellular turnover. Macrophage populations and their spatial distribution were found to fluctuate across the cycle. The number of macrophages was highest at diestrus, and the greatest number of macrophages in direct contact with epithelial cells occurred at proestrus. The physiological necessity of macrophages in mammary gland morphogenesis during the estrous cycle was demonstrated in Cd11b-Dtr transgenic mice. Ovariectomised mice were treated with estradiol and progesterone to stimulate alveolar development, and with the progesterone receptor antagonist mifepristone to induce regression of the newly formed alveolar buds. Macrophage depletion during alveolar development resulted in a reduction in both ductal epithelial cell proliferation and the number of alveolar buds. Macrophage depletion during alveolar regression resulted in an increased number of branch points and an accumulation of TUNEL-positive cells. These studies show that macrophages have two roles in the cellular turnover of epithelial cells in the cycling mammary gland; following ovulation, they promote the development of alveolar buds in preparation for possible pregnancy, and they remodel the tissue back to its basic architecture in preparation for a new estrous cycle.
Keywords: Mammary gland; macrophage; ovarian cycle; morphogenesis; mouse
Rights: © 2010. Published by The Company of Biologists Ltd
RMID: 0020101476
DOI: 10.1242/dev.059261
Appears in Collections:Obstetrics and Gynaecology publications

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