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https://hdl.handle.net/2440/62088
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Type: | Journal article |
Title: | LC-MS/MS for immunosuppressant therapeutic drug monitoring |
Author: | Sallustio, B. |
Citation: | Bioanalysis, 2010; 2(6):1141-1153 |
Publisher: | Future Science Ltd |
Issue Date: | 2010 |
ISSN: | 1757-6180 1757-6199 |
Statement of Responsibility: | Benedetta C. Sallustio |
Abstract: | Due to their narrow therapeutic indices and highly variable pharmacokinetics, therapeutic drug monitoring is necessary to individualize immunosuppressant dosage following organ transplantation. Until recently, monitoring was performed primarily using immunoassays, however, there is an increasing shift to HPLC coupled with MS/MS, due to its greater sensitivity and specificity. Online sample clean-up with either a single analytical column or with 2D chromatography significantly reduces manual handling and is essential to minimize matrix effects and maximize specificity and, coupled with rapid chromatography, allows the simultaneous analysis of the major immunosuppressants, with rapid sample throughput. Thus, LC–MS/MS is an attractive and versatile technique that facilitates rapid development of analytical methods, including new immunosuppressants as they become approved for clinical use. |
Keywords: | Humans Immunosuppressive Agents Drug Monitoring Artifacts Chromatography, Liquid Reproducibility of Results Tandem Mass Spectrometry |
Rights: | Copyright status unknown |
DOI: | 10.4155/BIO.10.58 |
Published version: | http://dx.doi.org/10.4155/bio.10.58 |
Appears in Collections: | Aurora harvest 5 Pharmacology publications |
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