Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/62088
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Type: Journal article
Title: LC-MS/MS for immunosuppressant therapeutic drug monitoring
Author: Sallustio, B.
Citation: Bioanalysis, 2010; 2(6):1141-1153
Publisher: Future Science Ltd
Issue Date: 2010
ISSN: 1757-6180
1757-6199
Statement of
Responsibility: 
Benedetta C. Sallustio
Abstract: Due to their narrow therapeutic indices and highly variable pharmacokinetics, therapeutic drug monitoring is necessary to individualize immunosuppressant dosage following organ transplantation. Until recently, monitoring was performed primarily using immunoassays, however, there is an increasing shift to HPLC coupled with MS/MS, due to its greater sensitivity and specificity. Online sample clean-up with either a single analytical column or with 2D chromatography significantly reduces manual handling and is essential to minimize matrix effects and maximize specificity and, coupled with rapid chromatography, allows the simultaneous analysis of the major immunosuppressants, with rapid sample throughput. Thus, LC–MS/MS is an attractive and versatile technique that facilitates rapid development of analytical methods, including new immunosuppressants as they become approved for clinical use.
Keywords: Humans; Immunosuppressive Agents; Drug Monitoring; Artifacts; Chromatography, Liquid; Reproducibility of Results; Tandem Mass Spectrometry
Rights: Copyright status unknown
RMID: 0020100778
DOI: 10.4155/BIO.10.58
Appears in Collections:Pharmacology publications

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