Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/62664
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Type: Journal article
Title: Direction-dependent conduction in lone atrial fibrillation
Author: Wong, C.
Stiles, M.
John, B.
Brooks, A.
Lau, D.
Dimitri, H.
Kuklik, P.
Shipp, N.
Sullivan, T.
Sanders, P.
Citation: Heart Rhythm, 2010; 7(9):1192-1199
Publisher: Elsevier Inc.
Issue Date: 2010
ISSN: 1547-5271
1556-3871
Statement of
Responsibility: 
Christopher X. Wonga, Martin K. Stiles, Bobby John, Anthony G. Brooks, Dennis H. Lau, Hany Dimitri, Pawel Kuklik, Nicholas J. Shipp, Thomas Sullivan and Prashanthan Sanders
Abstract: Patients with lone atrial fibrillation (AF) have an abnormal atrial substrate.The purpose of this study was to determine the role of direction-dependent conduction in patients with lone AF.Twenty-four patients with paroxysmal lone AF and 24 reference patients with left-sided accessory pathways were studied. Multipolar catheters placed at the lateral right atrium, crista terminalis, coronary sinus (CS), and left atrial roof were used to determine direction-dependent conduction characteristics. Biatrial electroanatomic maps were created during sinus rhythm and with distal CS pacing to characterize direction-dependent differences in conduction velocities, electrogram complexity, and voltage.Differing wavefront directions caused changes in conduction velocity (P <.001), biatrial activation times (P <.001), electrogram fragmentation (P <.001), site-specific conduction delays (P <.001), and voltage (P <.001) in both lone AF and reference patients. These direction-dependent abnormalities were amplified in lone AF patients compared to reference patients, who exhibited greater slowing in conduction velocities (P = .02), prolongation of biatrial activation time (P = .04), increase in number (P <.001) and length (P <.001) of lines of conduction block, increase in proportion of fractionated electrograms (P <.001), and decrease in voltage (P = .03) during distal CS pacing compared to sinus rhythm.This study demonstrates the marked direction-dependent conduction abnormalities present in patients with lone AF. These results provide further insights into the critical interplay between the underlying abnormal substrate and differing wavefront directions. The study suggests that direction-dependent conduction abnormalities may explain in part the greater arrhythmogenicity of ectopic triggers from the left atrium rather than the right atrium.
Keywords: Arrhythmia Atrial fibrillation; Atrial substrate; Direction dependence
Rights: Crown Copyright © 2010 Published by Elsevier Inc. on behalf of Heart Rhythm Society. All rights reserved.
RMID: 0020100773
DOI: 10.1016/j.hrthm.2010.05.037
Appears in Collections:Public Health publications

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