Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/62699
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Type: Journal article
Title: FUS mutations in amyotrophic lateral sclerosis: clinical, pathological, neurophysiological and genetic analysis
Author: Blair, I.
Williams, K.
Warraich, S.
Durnall, J.
Theong, A.
Manavis, J.
Blumbergs, P.
Vucic, S.
Kiernan, M.
Nicholson, G.
Citation: Journal of Neurology Neurosurgery and Psychiatry, 2010; 81(6):639-645
Publisher: British Med Journal Publ Group
Issue Date: 2010
ISSN: 0022-3050
1468-330X
Statement of
Responsibility: 
Ian P Blair, Kelly L Williams, Sadaf T Warraich, Jennifer C Durnall, Annora D Thoeng, Jim Manavis, Peter C Blumbergs, Steve Vucic, Matthew C Kiernan, Garth A Nicholson
Abstract: Objective: FUS gene mutations were recently identified in familial amyotrophic lateral sclerosis (ALS). The present studies sought to define the clinical, post-mortem and neurophysiological phenotypes in ALS families with FUS mutations and to determine the frequency of FUS mutations in familial and sporadic ALS. Methods: FUS was screened for mutations in familial and sporadic ALS cases. Clinical, post-mortem and neurophysiological features of large families with FUS mutations are described. Results and conclusions: FUS mutations were evident in 3.2% (4/124) of familial ALS, representing the second most common gene abnormality to be described in familial ALS after SOD1. No mutations were present in 247 sporadic ALS cases. The clinical presentation in 49 affected patients was consistent with a predominantly lower motor neuron disorder, supported by post-mortem findings. Upper motor neuron involvement varied, with Wallerian degeneration of corticospinal tracts present in one post-mortem case but absent in a second case from the same family. Features of cortical hyperexcitability demonstrated upper motor neuron involvement consistent with other forms of familial and sporadic ALS. One case presented with frontotemporal dementia (FTD) indicating that this may be a rare presenting feature in families with FUS mutation. Ubiquitin-positive cytoplasmic skein-like inclusions were present in lower motor neurons, but in contrast to sporadic ALS, no TDP-43 pathology was evident. Mutation-specific clinical features were identified. Patients with a R521C mutation were significantly more likely to develop disease at a younger age, and dropped-head syndrome was a frequent feature. Reduced disease penetrance was evident among most affected families.
Keywords: Brain; Humans; Amyotrophic Lateral Sclerosis; Ribonuclease, Pancreatic; Superoxide Dismutase; RNA-Binding Protein FUS; Microtubule-Associated Proteins; DNA-Binding Proteins; Vesicular Transport Proteins; Nerve Tissue Proteins; RNA, Messenger; Severity of Illness Index; DNA Mutational Analysis; Cognition Disorders; Neuropsychological Tests; Point Mutation; Adult; Aged; Middle Aged; Female; Male; Young Adult; Genetic Testing; Endosomal Sorting Complexes Required for Transport; Dynactin Complex; Superoxide Dismutase-1
Rights: Copyright © The Authors
RMID: 0020098045
DOI: 10.1136/jnnp.2009.194399
Appears in Collections:Pathology publications

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