Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/63118
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Escherichia coli subtilase cytotoxin
Author: Paton, A.
Paton, J.
Citation: Toxins, 2010; 2(2):215-228
Publisher: MDPI
Issue Date: 2010
ISSN: 2072-6651
2072-6651
Statement of
Responsibility: 
Adrienne W. Paton and James C. Paton
Abstract: Subtilase cytotoxin (SubAB) is the prototype of a new AB5 toxin family produced by a subset of Shiga toxigenic Escherichia coli (STEC) strains. Its A subunit is a subtilase-like serine protease and cytotoxicity for eukaryotic cells is due to a highly specific, single-site cleavage of BiP/GRP78, an essential Hsp70 family chaperone located in the endoplasmic reticulum (ER). This cleavage triggers a severe and unresolved ER stress response, ultimately triggering apoptosis. The B subunit has specificity for glycans terminating in the sialic acid N-glycolylneuraminic acid. Although its actual role in human disease pathogenesis is yet to be established, SubAB is lethal for mice and induces pathological features overlapping those seen in the haemolytic uraemic syndrome, a lifethreatening complication of STEC infection. The toxin is also proving to be a useful tool for probing the role of BiP and ER stress in a variety of cellular functions.
Keywords: subtilase cytotoxin; AB5 toxin; BiP/GRP78; endoplasmic reticulum stress; Shiga toxigenic Escherichia coli
Rights: © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
RMID: 0020103908
DOI: 10.3390/toxins2020215
Appears in Collections:Molecular and Biomedical Science publications

Files in This Item:
File Description SizeFormat 
hdl_63118.pdfPublished version182.26 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.