Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/63200
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Type: Journal article
Title: IgG responses to antigens from Dermatophagoides farinae in healthy and atopic dogs
Author: Hou, C.
Pemberton, A.
Nuttall, T.
Hill, P.
Citation: Veterinary Immunology and Immunopathology, 2005; 106(1-2):121-128
Publisher: Elsevier Science BV
Issue Date: 2005
ISSN: 0165-2427
1873-2534
Statement of
Responsibility: 
Chia-Chun Hou, Alan Pemberton, Tim Nuttall, Peter B. Hill
Abstract: In this study, we used a semi-quantitative electrophoresis and immunoblotting technique to characterise the IgG response to antigens from Dermatophagoides farinae in 20 healthy and 20 atopic dogs. Both groups mounted an IgG response to multiple antigens from the mite. There was no significant difference in the number of bands recognised, or the molecular weights of the bands, between the two groups. The two most obvious bands in both groups were proteins with molecular weights of 98 kDa (likely to be the high molecular weight allergen Der f 15) and 44 kDa, although dogs in both groups recognised a similar pattern of other antigens. The magnitude of the IgG response was greater in the atopic group although this was not statistically significant. The results indicate that the immune system of both healthy and atopic dogs generates an IgG response to multiple antigens from D. farinae. As some of these antigens (such as the 98 and 44 kDa proteins) are also targeted by IgE in atopic dogs, immunoglobulin class switching in response to Th2 cytokines may not be as dominant a process as has been proposed.
Keywords: Atopic dermatitis; Dermatophagoides farinae; IgG; Dogs
Rights: Copyright © 2005 Elsevier B.V. All rights reserved.
RMID: 0020103442
DOI: 10.1016/j.vetimm.2005.01.011
Appears in Collections:Animal and Veterinary Sciences publications

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