Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/64001
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dc.contributor.authorO'Callaghan, M.en
dc.contributor.authorMacLennan, A.en
dc.contributor.authorGibson, C.en
dc.contributor.authorMcMichael, G.en
dc.contributor.authorHaan, E.en
dc.contributor.authorBroadbent, J.en
dc.contributor.authorPriest, K.en
dc.contributor.authorGoldwater, P.en
dc.contributor.authorDekker, G.en
dc.date.issued2011en
dc.identifier.citationJournal of Paediatrics and Child Health, 2011; 47(3):99-110en
dc.identifier.issn1034-4810en
dc.identifier.issn1440-1754en
dc.identifier.urihttp://hdl.handle.net/2440/64001-
dc.description.abstractAim: Previous studies have proposed a link between the presence of specific single nucleotide polymorphisms (SNPs) and cerebral palsy and the majority of these associations remain to be confirmed or rejected by prospective studies with sufficient statistical power. Prior studies have also given little attention to the interaction of genomic characteristics and clinical risk factors. Methods: This paper describes the design of a prospective case-control study to test these genetic associations in conjunction with more stringent data collection in respect to clinical features associated with pregnancy, particularly maternal infection. Here we consider the ethical requirements, our hypothesis that genetic susceptibility modifies the risk of cerebral palsy in the presence of perinatal environmental triggers, a priori primary and secondary aims, power calculations, participant recruitment strategies, data linkage, sampling methods of genetic material and subsequent SNP analysis, collection of clinical data and the proposed final statistical analysis.en
dc.description.statementofresponsibilityMichael E. O’Callaghan, Alastair H. MacLennan, Catherine S. Gibson, Gai L. McMichael, Eric A. Haan, Jessica Broadbent, Kevin Priest, Paul N. Goldwater, Gustaaf A. Dekker for the Australian Collaborative Cerebral Palsy Research Groupen
dc.language.isoenen
dc.publisherBlackwell Publishing Asiaen
dc.rights© 2010 The Authors. Journal of Paediatrics and Child Health © 2010 Paediatrics and Child Health Division (Royal Australasian College of Physicians)en
dc.subjectcase-control; cerebral palsy; genetic; single nucleotide polymorphism (SNP).en
dc.titleThe Australian cerebral palsy research study - Protocol for a national collaborative study investigating genomic and clinical associations with cerebral palsyen
dc.typeJournal articleen
dc.identifier.rmid0020104828en
dc.identifier.doi10.1111/j.1440-1754.2010.01896.xen
dc.identifier.pubid31434-
pubs.library.collectionObstetrics and Gynaecology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidO'Callaghan, M. [0000-0001-5038-5859]en
dc.identifier.orcidMcMichael, G. [0000-0002-6811-5301]en
dc.identifier.orcidHaan, E. [0000-0002-7310-5124]en
dc.identifier.orcidDekker, G. [0000-0002-7362-6683]en
Appears in Collections:Obstetrics and Gynaecology publications
Cerebral Palsy Research Group publications

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