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https://hdl.handle.net/2440/64414
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Type: | Journal article |
Title: | Double-Walled Carbon Nanotubes as Nanosyringes |
Author: | Hilder, T. Hill, J. |
Citation: | Journal of Computational and Theoretical Nanoscience, 2008; 5(11):2153-2159 |
Publisher: | American Scientific Publishers |
Issue Date: | 2008 |
ISSN: | 1546-1955 1546-1963 |
Statement of Responsibility: | Tamsyn A. Hilder, James M. Hill |
Abstract: | Functionalized nanoparticles and nanotubes may be able to target specific cells, become ingested and then release their contents in response to a chemical trigger. An alternative delivery mechanism, which may offer advantages in drug delivery is the use of a nanosyringe which pierces the cell membrane and injects molecules such as DNA or anticancer drugs directly into the cell. Here, we propose the use of double-walled carbon nanotubes as nanosyringes. By way of illustration we investigate the suction and expulsion mechanisms, using elementary mechanics and applied mathematical modeling techniques, for both a C₆₀ fullerene and the anticancer drug cisplatin, but similar calculations can be undertaken for any molecule. Some specific guidelines are formulated to assist medical scientists to facilitate nanosyringe development. |
Keywords: | nanosyringe mechanics Cisplatin fullerene loading/unloading |
Rights: | Copyright status unknown |
DOI: | 10.1166/jctn.2008.1112 |
Published version: | http://dx.doi.org/10.1166/jctn.2008.1112 |
Appears in Collections: | Aurora harvest Mathematical Sciences publications |
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