Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/64858
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Abnormal postprandial PYY response in insulin sensitive nondiabetic subjects with a strong family history of type 2 diabetes
Author: Viardot, A.
Heilbronn, L.
Herzog, H.
Gregersen, S.
Campbell, L.
Citation: International Journal of Obesity, 2008; 32(6):943-948
Publisher: Nature Publishing Group
Issue Date: 2008
ISSN: 0307-0565
1476-5497
Statement of
Responsibility: 
A. Viardot, L.K. Heilbronn, H. Herzog, S. Gregersen, and L.V. Campbell
Abstract: Objective: Gut-derived hormone peptide YY (PYY) is low in subjects with obesity and type 2 diabetes (T2D). However, it is unknown whether this is a primary defect or a consequence of metabolic disturbances. In this study, we aimed to assess whether low fasting and postprandial PYY secretion is an early defect, potentially promoting the development of obesity and T2D, and whether it is modified by macronutrient content. Design: Prospective cross-sectional cohort study. Subjects: Nine individuals with a strong family history of T2D (REL) and seven age and adiposity matched individuals with no family history of T2D (CON). Interventions: Metabolic studies including hyperinsulinemic-euglycemic clamp, dual X-ray absorptiometry and two meal tests containing 1000 kcal with an either high fat (76%) or high carbohydrate (76%) content. Main outcome measures: Fasting and postprandial PYY levels were measured and analyzed for potential correlations with markers for adiposity and insulin resistance. Results: Insulin sensitivity was not different between REL and CON. Fasting glucose, insulin, triglycerides and PYY were also not different between groups. However, the postprandial incremental area under curve (AUC) of PYY was significantly lower in REL after the high carbohydrate (HCHO) meal (+27.3 vs +60.6% increase from baseline, P=0.038). The AUC of insulin during HCHO meal correlated negatively with both AUC and fasting level of PYY (r=−0.58 and −0.60, respectively, P<0.05). Conclusions: A blunted postprandial PYY secretion is observed in a very early stage in the development of T2D in genetically susceptible individuals. This defect precedes the presence of insulin resistance and adiposity, and could therefore predispose to the development of T2D.
Keywords: gastrointestinal hormones
type 2 diabetes
prediabetes
metabolism
PYY
Rights: © 2008 Nature Publishing Group
DOI: 10.1038/ijo.2008.24
Published version: http://dx.doi.org/10.1038/ijo.2008.24
Appears in Collections:Aurora harvest
Molecular and Biomedical Science publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.