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https://hdl.handle.net/2440/64955
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Type: | Journal article |
Title: | Transcript elongation by RNA polymerase II |
Author: | Selth, L. Sigurdsson, S. Svejstrup, J. |
Citation: | Annual Review of Biochemistry, 2010; 79(1):271-293 |
Publisher: | Annual Reviews |
Issue Date: | 2010 |
ISSN: | 0066-4154 0066-4154 |
Editor: | Kornberg, R.D. Raetz, C.R.H. Rothman, J.E. Thorner, J.W. |
Statement of Responsibility: | Luke A. Selth, Stefan Sigurdsson, and Jesper Q. Svejstrup |
Abstract: | Until recently, it was generally assumed that essentially all regulation of transcription takes place via regions adjacent to the coding region of a gene—namely promoters and enhancers—and that, after recruitment to the promoter, the polymerase simply behaves like a machine, quickly “reading the gene.” However, over the past decade a revolution in this thinking has occurred, culminating in the idea that transcript elongation is extremely complex and highly regulated and, moreover, that this process significantly affects both the organization and integrity of the genome. This review addresses basic aspects of transcript elongation by RNA polymerase II (RNAPII) and how it relates to other DNA-related processes. |
Keywords: | chromatin elongation factors gene traffic transcription-associated recombination transcription-repair coupling |
Rights: | Copyright © 2010 by Annual Reviews. All rights reserved |
DOI: | 10.1146/annurev.biochem.78.062807.091425 |
Published version: | http://dx.doi.org/10.1146/annurev.biochem.78.062807.091425 |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 5 |
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