Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/65673
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Association of the COMT val158met Variant with Antidepressant Treatment Response in Major Depression |
Author: | Baune, B. Hohoff, C. Berger, K. Neumann, A. Mortensen, S. Roehrs, T. Deckert, J. Arolt, V. Domschke, K. |
Citation: | Neuropsychopharmacology, 2008; 33(4):924-932 |
Publisher: | Elsevier Science Inc |
Issue Date: | 2008 |
ISSN: | 0893-133X 1740-634X |
Statement of Responsibility: | Bernhard T Baune, Christa Hohoff, Klaus Berger, Anna Neumann, Sünke Mortensen, Tilmann Roehrs, Jürgen Deckert, Volker Arolt and Katharina Domschke |
Abstract: | In several previous biochemical, pharmacological, and genetic studies, the catechol-O-methyltransferase (COMT) has been suggested to be involved in the pathogenesis as well as the pharmacological treatment of affective disorders. In the present study, 256 patients with major depression (DSM-IV) of Caucasian descent were genotyped for the functional COMT val158met polymorphism and characterized for clinical response to antidepressive pharmacological treatment as measured by intra-individual changes of Hamilton Depression (HAM-D-21) scores over 6 weeks. The COMT 158val/val genotype conferred a significant risk of worse response after 4–6 weeks of antidepressant treatment in patients with major depression (week 4: p=0.003; week 5: p<0.0001; week 6: p<0.0001) after Bonferroni correction for multiple comparisons. The present results strongly point toward a negative influence of the higher activity COMT 158val/val genotype on antidepressant treatment response during the first 6 weeks of pharmacological treatment in major depression, possibly conferred by consecutively decreased dopamine availability. This finding suggests a potentially beneficial effect of an antidepressive add-on therapy with substances increasing dopamine availability individually tailored according to COMT val158met genotype. |
Keywords: | major depression catechol-O-methyltransferase COMT val158met polymorphism antidepressants treatment response |
Rights: | © 2008 Nature Publishing Group. All rights reserved. |
DOI: | 10.1038/sj.npp.1301462 |
Published version: | http://dx.doi.org/10.1038/sj.npp.1301462 |
Appears in Collections: | Aurora harvest Psychiatry publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.