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|Title:||HTR2A gene variation is involved in antidepressant treatment response|
|Citation:||European Neuropsychopharmacology, 2010; 20(1):65-68|
|Publisher:||Elsevier Science BV|
|Susanne Lucae, Marcus Ising, Sonja Horstmann, Bernhard T. Baune, Volker Arolt, Bertram Müller-Myhsok, Florian Holsboer, Katharina Domschke|
|Abstract:||Two serotonin 2A receptor (HTR2A) SNPs recently reported to be associated with antidepressant treatment response in STARD (rs7997012; rs1928040) were analyzed for association with treatment response in two independent Caucasian samples of patients with a Major Depressive Episode. In the combined sample (n=637) SNP rs7997012 was significantly associated with remission after five weeks providing first replicative support for the initial finding, with, however, an inverse allelic association as compared to the STARD sample.|
|Keywords:||HTR2A; Pharmacogenetics; SNP; Treatment response; Major Depression; Association study|
|Rights:||© 2009 Elsevier B.V. and ECNP All rights reserved.|
|Appears in Collections:||Psychiatry publications|
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