Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/65809
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Association between cytokines and cerebral MRI changes in the aging brain
Author: Baune, B.
Ponath, G.
Rothermundt, M.
Roesler, A.
Berger, K.
Citation: Journal of Geriatric Psychiatry and Neurology, 2009; 22(1):23-34
Publisher: Decker Periodicals Inc
Issue Date: 2009
ISSN: 0891-9887
1552-5708
Statement of
Responsibility: 
Bernhard T. Baune, Gerald Ponath, Matthias Rothermundt, Andreas Roesler and Klaus Berger
Abstract: The association between cytokines (IL-1β, sIL-4R, IL-6, IL-8, IL-10, IL-12, TNF-α) and subcortical white matter lesions, cortical atrophy and lacunar infarctions of the aging brain was investigated among 268 elderly community participants. Single pro- and anti-inflammatory cytokines were neither associated with WML nor with atrophy and lacunar infarction. An association between atrophy and the chemokine-cytokine factor (containing sIL-4R, IL-6, IL-8) remained significant after adjustment for age, gender, education, depressive symptoms, diabetes mellitus, cardiovascular diseases (stroke, TIA, myocardial infarction, myocardial insufficiency, arrhythmic heart), hypertension, body-mass index, smoking status and aggregation inhibitors as opposed to single cytokines. Atrophy of the parietal, temporal and occipital lobes was associated with the same cytokinechemokine factor for both the whole sample or restricted to those without history of stroke/TIA. The results indicate that a combination of chemokine-cytokines rather than single cytokines may contribute to inflammatory processes associated with cortical atrophy in the aging brain.
Keywords: white matter lesions
atrophy
lacunar infarctions
aging
cytokines
Rights: © 2009 Sage Publications
DOI: 10.1177/0891988708328216
Published version: http://dx.doi.org/10.1177/0891988708328216
Appears in Collections:Aurora harvest
Psychiatry publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.