Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/65995
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Type: Journal article
Title: Adjunctive antidepressant treatment with quetiapine in agitated depression: positive effects on symptom reduction, psychopathology and remission rates
Author: Dannlowski, U.
Baune, B.
Bockermann, I.
Domschke, K.
Evers, S.
Arolt, V.
Hetzel, G.
Rothermundt, M.
Citation: Human Psychopharmacology-Clinical and Experimental, 2008; 23(7):587-593
Publisher: John Wiley & Sons Ltd
Issue Date: 2008
ISSN: 0885-6222
1099-1077
Statement of
Responsibility: 
Udo Dannlowski, Bernhard T. Baune, Iris Böckermann, Katharina Domschke, Stefan Evers, Volker Arolt, Günter Hetzel and Matthias Rothermundt
Abstract: OBJECTIVES: To investigate the adjunctive effects of quetiapine on overall treatment response and on specific symptoms in agitated depression. METHODS: Twenty-one patients suffering from an acute agitated major depressive episode were enrolled in the quetiapine/venlafaxine study group (QUET) in the context of a 6-week open-label, flexible dose, non-randomized case-control study. Eighteen matched depressed patients treated with antidepressants only served as controls (CON). Clinical assessment was carried out by the use of Hamilton Rating Scale for Depression (HAM-D) 21 scale. RESULTS: Both groups had high HAM-D scores at baseline (27.6 vs. 27.5; p = 0.94). The QUET group displayed a significantly larger HAM-D decrease already after 1 week of treatment (p = 0.026, d = 0.77). This group difference increased slightly until week 6 (p = 0.005, d = 1.0). The remission rate in the QUET group (70%) was almost double that of the CON group (38.5%), p = 0.022. The overall effect originated from various HAM-D items indicating agitation, sleep problems and anxiety. CONCLUSIONS: Adjunctive quetiapine treatment in agitated depression showed faster and greater response leading to higher remission rates compared with antidepressants alone. Overall clinical improvement was specifically related to single aspects of psychopathology indicating that quetiapine develops its positive effects through a variety of psychopharmacological properties.
Keywords: quetiapine; agitation; major depression; sleep; adjunctive treatment
Rights: Copyright © 2008 John Wiley & Sons, Ltd.
RMID: 0020111400
DOI: 10.1002/hup.963
Appears in Collections:Psychiatry publications

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