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Type: Journal article
Title: Neuropeptide Y (NPY) gene: Impact on emotional processing and treatment response in anxious depression
Author: Domschke, K.
Dannlowski, U.
Hohoff, C.
Ohrmann, P.
Bauer, J.
Kugel, H.
Zwanzger, P.
Heindel, W.
Deckert, J.
Arolt, V.
Suslow, T.
Baune, B.
Citation: European Neuropsychopharmacology, 2010; 20(5):301-309
Publisher: Elsevier Science BV
Issue Date: 2010
ISSN: 0924-977X
Statement of
Katharina Domschke, Udo Dannlowski, Christa Hohoff, Patricia Ohrmann, Jochen Bauer, Harald Kugel, Peter Zwanzger, Walter Heindel, Jürgen Deckert, Volker Arolt, Thomas Suslow, Bernhard T. Baune
Abstract: Neuropeptide Y (NPY) has been found to play a role in the pathomechanism of both anxiety and depression. Thus, NPY is a promising candidate in the investigation of the clinical phenotype of "anxious depression". Five NPY gene variants were investigated for an influence on antidepressant treatment response in a sample of 256 patients with depression. Additionally, NPY gene impact on amygdala activation during facial emotion processing was analyzed in a subsample of 35 depressed patients. Particularly in anxious depression, the less active NPY rs16147 -399C allele conferred slow response after 2weeks and failure to achieve remission after four weeks of treatment. The rs16147 C allele was further associated with stronger bilateral amygdala activation in response to threatening faces in an allele-dose fashion. The present results point towards a possible influence of functional NPY gene variation on antidepressant treatment response in anxious depression, potentially conveyed by altered emotional processing.
Keywords: Pharmacogenetics; Imaging genetics; Depression; Anxiety; NPY
Rights: © 2009 Elsevier B.V. and ECNP. All rights reserved.
RMID: 0020111371
DOI: 10.1016/j.euroneuro.2009.09.006
Appears in Collections:Psychiatry publications

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