Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/66140
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Type: Journal article
Title: Moderate weight loss improves heart rate variability in overweight and obese adults with type 2 diabetes
Author: Sjoberg, N.
Brinkworth, G.
Wycherley, T.
Noakes, M.
Saint, D.
Citation: Journal of Applied Physiology, 2011; 110(4):1060-1064
Publisher: Amer Physiological Soc
Issue Date: 2011
ISSN: 8750-7587
0021-8987
Statement of
Responsibility: 
Nicholas Sjoberg, Grant D. Brinkworth, Thomas P. Wycherley, Manny Noakes, and David A. Saint
Abstract: The objective of this study was to determine the effects of weight loss on heart rate variability (HRV) and its association with traditional cardiovascular disease risk factors in overweight and obese patients with type 2 diabetes. Forty five patients [body mass index (BMI) 35.4 ± 0.7 kg/m2; age 56.5 ± 1.1 yr] with type 2 diabetes followed an energy-restricted diet (6–7 MJ/day) for 16 wk. Body weight, blood pressure, glucose, insulin, insulin resistance [homeostasis model assessment index 2 (HOMA2)], glycosylated hemoglobin (HbA1c), total cholesterol, low-density lipoproteins (LDL), high-density lipoproteins (HDL), triglycerides, resting HR, and HRV were measured before and after the intervention period. Mean reduction in body weight was 11.1 ± 1.0 kg (10%), with significant reductions in blood pressure (−10%), total cholesterol (−15.9%), LDL (−17.7%), HDL (−7.5%), triglycerides (−21.2%), glucose (−23.4%), insulin (−37.6%), HOMA2 (−40.1%), and HbA1c (−14.5%) (P ≤ 0.05 for all variables). There were increases in several HRV components, including total power (1,370 ± 280 to 2,045 ± 280 ms2), low-frequency power (345 ± 70 to 600 ± 108 ms2), SD of normal to normal intervals (SDNN; 35.0 ± 2.5 to 43.0 ± 2.7 s), and square root of the mean squared differences of successive normal to normal intervals (RMSSD; 23.0 ± 3.5 to 32.0 ± 3.1 s), and a decrease in HR (69.0 ± 1.3 to 60.0 ± 1.2 beats/min) (P ≤ 0.03 for all variables). Changes in HR, SDNN, total power, and low-frequency power correlated with change in BMI (P < 0.05). In addition to improvements in traditional cardiovascular and metabolic risk factors, weight loss improves HRV in overweight and obese patients with type 2 diabetes.
Keywords: diabetic autonomic dysfunction; cardiovascular risk factors; autonomic cardiovascular control
Rights: Copyright © 2011 the American Physiological Society
RMID: 0020105702
DOI: 10.1152/japplphysiol.01329.2010
Appears in Collections:Physiology publications

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