Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/66472
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Chronic phase shifts of the photoperiod throughout pregnancy programs glucose intolerance and insulin resistance in the rat |
Author: | Varcoe, T. Wight, N. Voultsios, A. Salkeld, M. Kennaway, D. |
Citation: | PLoS One, 2011; 6(4):1-10 |
Publisher: | Public Library of Science |
Issue Date: | 2011 |
ISSN: | 1932-6203 1932-6203 |
Editor: | Yamazaki, S. |
Statement of Responsibility: | Tamara J. Varcoe, Nicole Wight, Athena Voultsios, Mark D. Salkeld and David J. Kennaway |
Abstract: | Shift work during pregnancy is associated with an increased risk for preterm birth and low birth weight. However, the impact upon the long term health of the children is currently unknown. In this study, we used an animal model to determine the consequences of maternal shift work exposure on the health of the adult offspring. Pregnant rats were exposed to chronic phase shifts (CPS) in their photoperiod every 3–4 days throughout gestation and the first week after birth. Adult offspring were assessed for a range of metabolic, endocrine, circadian and neurobehavioural parameters. At 3 months of age, male pups exposed to the CPS schedule in utero had increased adiposity (+29%) and hyperleptinaemia (+99% at 0700h). By 12 months of age, both male and female rats displayed hyperleptinaemia (+26% and +41% respectively) and hyperinsulinaemia (+110% and +83% respectively). 12 month old female CPS rats displayed poor glucose tolerance (+18%) and increased insulin secretion (+29%) in response to an intraperitoneal glucose tolerance test. In CPS males the glucose response was unaltered, but the insulin response was reduced by 35%. The glucose response to an insulin tolerance test was decreased by 21% in CPS females but unaltered in males. Disruption of circadian rhythmicity during gestation resulted in gender dependent metabolic consequences for the adult offspring. These results highlight the need for a thorough analysis of shift work exposure in utero on the health of the adult offspring in humans. |
Keywords: | Nervous System Animals Animals, Newborn Rats Rats, Wistar Glucose Intolerance Insulin Resistance Glucose Tolerance Test Pregnancy Outcome Behavior, Animal Body Composition Circadian Rhythm Aging Pregnancy Photoperiod Time Factors Female Male |
Description: | Extent: 10p. |
Rights: | Copyright 2011 Varcoe et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
DOI: | 10.1371/journal.pone.0018504 |
Published version: | http://dx.doi.org/10.1371/journal.pone.0018504 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_66472.pdf | Published version | 699.57 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.