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https://hdl.handle.net/2440/66668
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Type: | Journal article |
Title: | Identification of Streptococcus pneumoniae Cps2C residues that affect capsular polysaccharide polymerization, cell wall ligation, and Cps2D phosphorylation |
Author: | Byrne, J. Morona, J. Paton, J. Morona, R. |
Citation: | Journal of Bacteriology, 2011; 193(9):2341-2346 |
Publisher: | Amer Soc Microbiology |
Issue Date: | 2011 |
ISSN: | 0021-9193 1098-5530 |
Statement of Responsibility: | James P. Byrne, Judy K. Morona, James C. Paton, and Renato Morona |
Abstract: | A number of single amino acid substitutions throughout Streptococcus pneumoniae Cps2C were found to affect its function and confer either a mucoid or a small colony phenotype. These mutants exhibit significant changes in capsular polysaccharide (CPS) profile relative to that of wild-type pneumococci. The introduced mutations affect either polymerization or ligation of CPS to the cell wall and/or Cps2D phosphorylation. |
Keywords: | Cell Wall Streptococcus pneumoniae Polysaccharides, Bacterial Bacterial Capsules Bacterial Proteins Amino Acid Substitution Gene Expression Regulation, Bacterial Amino Acid Sequence Mutation |
Rights: | Copyright © 2011, American Society for Microbiology. All Rights Reserved. |
DOI: | 10.1128/JB.00074-11 |
Published version: | http://dx.doi.org/10.1128/jb.00074-11 |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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