Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/66884
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Type: Journal article
Title: The oligosaccharide α-cyclodextrin has modest effects to slow gastric emptying and modify the glycaemic response to sucrose in healthy older adults
Other Titles: The oligosaccharide alpha-cyclodextrin has modest effects to slow gastric emptying and modify the glycaemic response to sucrose in healthy older adults
Author: Gentilcore, D.
Vanis, L.
Teng, J.
Wishart, J.
Buckley, J.
Rayner, C.
Horowitz, M.
Jones, K.
Citation: British Journal of Nutrition, 2011; 106(4):583-587
Publisher: C A B I Publishing
Issue Date: 2011
ISSN: 0007-1145
1475-2662
Statement of
Responsibility: 
Diana Gentilcore, Lora Vanis, Jasmine C. Teng, Judith M. Wishart, Jonathan D. Buckley, Christopher K. Rayner, Michael Horowitz and Karen L. Jones
Abstract: In healthy older subjects, the glycaemic response to carbohydrate-containing meals is dependent on gastric emptying and intestinal absorption; when the latter is slowed, the magnitude of the rise in glucose is attenuated. The oligosaccharide α-cyclodextrin has been reported to diminish the glycaemic response to starch in young adults; this effect has been attributed to the inhibition of pancreatic amylase. We examined the effects of α-cyclodextrin on gastric emptying of, and the glycaemic and insulinaemic responses to, oral sucrose in healthy older subjects; as sucrose is hydrolysed by intestinal disaccharides, any effect(s) of α-cyclodextrin would not be attributable to amylase inhibition. A total of ten subjects (seven males and three females, age 68–76 years) were studied on 2 d. Gastric emptying, blood glucose and serum insulin were measured after ingestion of a 300 ml drink containing 100 g sucrose, labelled with 99mTc-sulphur colloid, with or without 10 g α-cyclodextrin. Gastric emptying was slowed slightly by α-cyclodextrin; this effect was evident between 135 and 195 min and was associated with a slight increase (P < 0·05) in distal stomach retention. After α-cyclodextrin, blood glucose was slightly less (P < 0·05) at 60 min, and serum insulin was less (P < 0·0005) at 90 and 120 min. There was no difference in the incremental areas under the curve (iAUC) for blood glucose, but there was a trend for the iAUC for serum insulin to be lower (P = 0·09) after α-cyclodextrin. We conclude that in a dose of 10 g, α-cyclodextrin has modest effects to slow gastric emptying of, and modify the glycaemic and insulinaemic responses to, oral sucrose, probably due to delayed intestinal carbohydrate absorption.
Keywords: Gastric emptying: Glycaemia: Cyclodextrin: Elderly
Rights: Copyright © The Authors 2011
RMID: 0020112463
DOI: 10.1017/S0007114511000444
Appears in Collections:Medicine publications

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