Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/6786
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Type: Journal article
Title: Genetically modified animal models as tools for studying bone and mineral metabolism
Author: Davey, R.
MacLean, H.
McManus, J.
Findlay, D.
Zajac, J.
Citation: Journal of Bone and Mineral Research, 2004; 19(6):882-892
Publisher: Amer Soc Bone & Mineral Res
Issue Date: 2004
ISSN: 0884-0431
1523-4681
Abstract: Genetic modification of mice is a powerful tool for the study of bone development and metabolism. This review discusses the advantages and disadvantages of various approaches used in bone-related research and the contributions these studies have made to bone biology. Genetic modification of mice is a powerful tool for the study of bone development and metabolism. This review discusses the advantages and disadvantages of various approaches used in bone-related research and the contributions these studies have made to bone biology. The approaches to genetic modification included in this review are (1) overexpression of genes, (2) global gene knockouts, (3) tissue-specific gene deletion, and (4) gene knock-in models. This review also highlights issues that should be considered when using genetically modified animal models, including the rigorous control of genetic background, use of appropriate control lines, and confirmation of tissue specificity of gene expression where appropriate. This technology provides a unique and powerful way to probe the function of genes and is already revolutionizing our approach to understanding the physiology of bone development and metabolism.
Keywords: Bone and Bones; Animals; Animals, Genetically Modified; Mice, Knockout; Mice; Minerals; Models, Animal; Phenotype
RMID: 0020040896
DOI: 10.1359/JBMR.040206
Appears in Collections:Orthopaedics and Trauma publications

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