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https://hdl.handle.net/2440/68299
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Type: | Journal article |
Title: | Effects of necrotic enteritis challenge on intestinal micro-architecture and mucin profile |
Author: | Golder, H. Geier, M. Forder, R. Hynd, P. Hughes, R. |
Citation: | British Poultry Science, 2011; 52(4):500-506 |
Publisher: | Carfax Publishing |
Issue Date: | 2011 |
ISSN: | 0007-1668 1466-1799 |
Statement of Responsibility: | H.M. Golder, M.S. Geier, R.E.A. Forder, P.I. Hynd & R.J. Hughes |
Abstract: | 1. This study investigated the effect of Eimeria spp./Clostridium perfringens induced necrotic enteritis and traditional antibiotic preventatives on intestinal micro-architecture and mucin profile. 2. A total of 600 Cobb 500 broiler chickens were randomly assigned to the following three groups: (i) unchallenged, (ii) challenged, and (iii) zinc bacitracin/monensin (ZnB/monensin) (n = 25 chickens/pen, 8 pens/group). The challenged and ZnB/monensin chickens were individually inoculated with Eimeria acervulina, E. maxima and E. tenella and C. perfringens type A (EHE-NE18) at 9 and 15 d post-hatch respectively, to induce necrotic enteritis. 3. The challenge procedure significantly decreased villus height, increased villus width and increased crypt depth in the challenged compared to the unchallenged chickens. Zinc bacitracin and monensin maintained villus-crypt structure similar to that of the unchallenged chickens. 4. Mucin profile was not affected by Eimeria spp./C. perfringens challenge as demonstrated by periodic acid-Schiff and high iron diamine-alcian blue pH 2·5 staining. Zinc bacitracin and monensin decreased the number of intestinal mucin-containing goblet cells. 5. Lectin histochemistry showed a trend towards greater Arachis hypogea (PNA) reactivity in unchallenged chickens. 6. In summary, Eimeria spp./C. perfringens challenge disrupted intestinal micro-architecture; however, challenge did not appear to affect intestinal mucin profile. Traditional antibiotics, zinc bacitracin and monensin maintained micro-architecture. |
Keywords: | Intestines Goblet Cells Animals Chickens Eimeria Clostridium perfringens Clostridium Infections Coccidiosis Enteritis Intestinal Diseases Poultry Diseases Necrosis Monensin Bacitracin Mucins Lectins Anti-Bacterial Agents Coccidiostats Random Allocation Species Specificity South Australia |
Rights: | © 2011 British Poultry Science Ltd. |
DOI: | 10.1080/00071668.2011.587183 |
Published version: | http://dx.doi.org/10.1080/00071668.2011.587183 |
Appears in Collections: | Animal and Veterinary Sciences publications Aurora harvest |
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