1. Adelaide Research & Scholarship
  2. Schools and Disciplines
  3. School of Earth and Environmental Sciences
  4. Earth and Environmental Sciences publications
Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/68314
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLiu, L.-
dc.contributor.authorGhosh, N.-
dc.contributor.authorSlivka, P.-
dc.contributor.authorFiorini, Z.-
dc.contributor.authorHutchinson, M.-
dc.contributor.authorWatkins, L.-
dc.contributor.authorYin, H.-
dc.date.issued2011-
dc.identifier.citationChemBioChem: a European journal of chemical biology, 2011; 12(12):1827-1831-
dc.identifier.issn1439-4227-
dc.identifier.issn1439-7633-
dc.identifier.urihttp://hdl.handle.net/2440/68314-
dc.description.abstractA truncated peptide was shown to retain the structure of the TLR4-binding hot-spot region of MD2, disrupting with the TLR4/MD2 interactions. The peptide not only demonstrated strong binding affinity in the fluorescence polarization assay, but also showed high specificity in macrophage cells. Furthermore, MD2-I was able to suppress neuropathic pain in animal models.-
dc.description.statementofresponsibilityLiping Liu, Nilanjan Ghosh, Peter F. Slivka, Zeno Fiorini, Mark R. Hutchinson, Linda R. Watkins and Hang Yin-
dc.language.isoen-
dc.publisherWiley-VCH Verlag GMBH-
dc.rightsCopyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim-
dc.source.urihttp://dx.doi.org/10.1002/cbic.201100211-
dc.subjectNeuroglia-
dc.subjectCell Line-
dc.subjectMacrophages-
dc.subjectAnimals-
dc.subjectHumans-
dc.subjectMice-
dc.subjectRats-
dc.subjectNeuralgia-
dc.subjectInflammation-
dc.subjectNitrobenzenes-
dc.subjectAzoles-
dc.subjectLipopolysaccharides-
dc.subjectPeptide Fragments-
dc.subjectSpectrometry, Fluorescence-
dc.subjectT-Cell Antigen Receptor Specificity-
dc.subjectMolecular Mimicry-
dc.subjectAmino Acid Sequence-
dc.subjectProtein Binding-
dc.subjectMolecular Sequence Data-
dc.subjectToll-Like Receptor 4-
dc.subjectLymphocyte Antigen 96-
dc.subjectMolecular Dynamics Simulation-
dc.subjectPain Management-
dc.titleAn MD2 hot-spot-mimicking peptide that suppresses TLR4-mediated inflammatory response in vitro and in vivo-
dc.typeJournal article-
dc.identifier.doi10.1002/cbic.201100211-
dc.relation.granthttp://purl.org/au-research/grants/arc/DP110100297-
pubs.publication-statusPublished-
dc.identifier.orcidHutchinson, M. [0000-0003-2154-5950]-
Appears in Collections:Aurora harvest
Earth and Environmental Sciences publications
Environment Institute publications

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.