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Type: Journal article
Title: Determinants of insulin responsiveness in young women: Impact of polycystic ovarian syndrome, nitric oxide, and vitamin D
Author: Ngo, D.
Chan, W.
Rajendran, S.
Heresztyn, T.
Amarasekera, A.
Sverdlov, A.
O'Loughlin, P.
Morris, H.
Chirkov, Y.
Norman, R.
Horowitz, J.
Citation: Nitric Oxide-Biology and Chemistry, 2011; 25(3):326-330
Publisher: Academic Press Inc Elsevier Science
Issue Date: 2011
ISSN: 1089-8603
Statement of
D.T.M. Ngo, W.P. Chan, S. Rajendran, T. Heresztyn, A. Amarasekera, A.L. Sverdlov, P.D. O’Loughlin, H.A. Morris, Y.Y. Chirkov, R.J. Norman, J.D. Horowitz
Abstract: Polycystic ovary syndrome (PCOS) is associated with incremental risk of atherosclerosis and possibly of cardiovascular events. Insulin resistance (IR) occurs frequently in PCOS subjects, which might be one of the mechanisms involved in engendering such risk. We sought to evaluate whether the impact of other factors potentially associated both with PCOS and with IR might differentially modulate degree of IR in women with and without PCOS.We measured body mass index (BMI), hs-CRP, plasma concentrations of asymmetric dimethylarginine (ADMA), vitamin D (25(OH)D3) levels and platelet responsiveness to nitric oxide donor sodium nitroprusside (NO responsiveness) in 47 young women (n=27 with PCOS and n=20 weight-matched controls) without metabolic syndrome, hypertension or overt cardiovascular disease. We performed univariate and multivariate regression analyses to establish correlates of the quantitative insulin-sensitivity check index (QUICKI), as a marker of IR. On univariate analysis, plasma 25(OH)D3 levels and low NO responsiveness tended to be direct correlates with QUICKI in the entire subject group. BMI, hs-CRP, and ADMA levels were significant inverse correlates of QUICKI in PCOS subjects, but not in subjects without PCOS. On multivariate analysis, NO responsiveness, and 25(OH)D3 levels, but not PCOS per se were significant correlates of QUICKI.In the entire cohort of young women, low NO responsiveness and vitamin D deficiency are associated with low QUICKI, while elevated ADMA, inflammatory activation and obesity are selectively associated with low QUICKI in PCOS subjects; this may contribute to the increased cardiovascular risk associated with this syndrome.
Keywords: Insulin resistance; Asymmetric dimethylarginine; Vitamin D; Polycystic ovary syndrome; Women health; Obesity
Rights: Copyright © 2011 Elsevier Inc. All rights reserved.
RMID: 0020113497
DOI: 10.1016/j.niox.2011.06.005
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