Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/68527
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Type: Journal article
Title: Immediate and longer term immunogenicity of a single dose of the combined haemophilus influenzae type B-Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age
Author: Booy, R.
Richmond, P.
Nolan, T.
McVernon, J.
Marshall, H.
Nissen, M.
Reynolds, G.
Ziegler, J.
Heron, L.
Lambert, S.
Caubet, M.
Mesaros, N.
Boutriau, D.
Citation: Pediatric Infectious Disease Journal, 2011; 30(4):340-342
Publisher: Lippincott Williams & Wilkins
Issue Date: 2011
ISSN: 0891-3668
1532-0987
Statement of
Responsibility: 
Robert Booy, Peter Richmond, Terry Nolan, Jodie McVernon, Helen Marshall, Michael Nissen, Graham Reynolds, John B. Ziegler, Leon Heron, Stephen Lambert, Magalie Caubet, Narcisa Mesaros and Dominique Boutriau
Abstract: Hib-primed but MenC-naive toddlers (N = 433) were randomized to receive 1 dose of Hib-MenC-TT or separate Hib-TT and MenC-CRM197 vaccines. One month later, noninferiority was demonstrated for serum bactericidal anti-MenC antibodies (rSBA) and Hib antipolyribosylribitol phosphate (PRP) antibodies; >99% in both groups had rSBA titer ≥ 8 or anti-PRP concentration ≥ 0.15 μg/mL. After 12 months, rSBA titer ≥ 8 persisted in 86.7% and 76.4%, and anti-PRP concentration ≥ 0.15 μg/mL persisted in 98.8% and 100% of children, respectively.
Keywords: Haemophilus influenzae type b; Neisseria meningitidis serogroup C; antibody persistence; toddlers
Rights: © 2011 Lippincott Williams & Wilkins, Inc.
RMID: 0020104381
DOI: 10.1097/INF.0b013e31820013d2
Appears in Collections:Paediatrics publications

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