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https://hdl.handle.net/2440/68527
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Type: | Journal article |
Title: | Immediate and longer term immunogenicity of a single dose of the combined haemophilus influenzae type B-Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age |
Author: | Booy, R. Richmond, P. Nolan, T. McVernon, J. Marshall, H. Nissen, M. Reynolds, G. Ziegler, J. Heron, L. Lambert, S. Caubet, M. Mesaros, N. Boutriau, D. |
Citation: | The Pediatric Infectious Disease Journal, 2011; 30(4):340-342 |
Publisher: | Lippincott Williams & Wilkins |
Issue Date: | 2011 |
ISSN: | 0891-3668 1532-0987 |
Statement of Responsibility: | Robert Booy, Peter Richmond, Terry Nolan, Jodie McVernon, Helen Marshall, Michael Nissen, Graham Reynolds, John B. Ziegler, Leon Heron, Stephen Lambert, Magalie Caubet, Narcisa Mesaros and Dominique Boutriau |
Abstract: | Hib-primed but MenC-naive toddlers (N = 433) were randomized to receive 1 dose of Hib-MenC-TT or separate Hib-TT and MenC-CRM197 vaccines. One month later, noninferiority was demonstrated for serum bactericidal anti-MenC antibodies (rSBA) and Hib antipolyribosylribitol phosphate (PRP) antibodies; >99% in both groups had rSBA titer ≥ 8 or anti-PRP concentration ≥ 0.15 μg/mL. After 12 months, rSBA titer ≥ 8 persisted in 86.7% and 76.4%, and anti-PRP concentration ≥ 0.15 μg/mL persisted in 98.8% and 100% of children, respectively. |
Keywords: | Haemophilus influenzae type b Neisseria meningitidis serogroup C antibody persistence toddlers |
Rights: | © 2011 Lippincott Williams & Wilkins, Inc. |
DOI: | 10.1097/INF.0b013e31820013d2 |
Published version: | http://dx.doi.org/10.1097/inf.0b013e31820013d2 |
Appears in Collections: | Aurora harvest Paediatrics publications |
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