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Type: Journal article
Title: Synthesis and physicochemical properties of biocompatible N-carboxyethylchitosan
Author: Pan, Y.
Luo, X.
Zhu, A.
Dai, S.
Citation: Journal of Biomaterials Science-polymer Edition, 2009; 20(7-8):981-992
Publisher: VSP BV
Issue Date: 2009
ISSN: 0920-5063
Statement of
Yingnan Pan, Xiadan Luo, Aiping Zhu and Sheng Dai
Abstract: A novel simple method was developed to successfully synthesize biocompatible N-carboxyethylchitosan (NCECS) with a substitution degree of approx. 41% using the Michael addition reaction. The NCECS structure was characterized by Fourier transform infra-red spectrometry (FT-IR), 1H-NMR, elemental analysis, X-ray diffraction spectrometry (XRD) and thermogravimetric analysis (TGA). The physicochemical properties of NCECS in solution are found to be strongly dependent on the pH value. In the pH range of 5.0-5.5, NCECS aggregates in dilute aqueous solution as evident by steady-state fluorescence spectroscopy and viscosimetry. The aggregated NCECS shows a spheric morphology from the atomic force microscopy (AFM) study. The possible aggregation mechanism was discussed.
Keywords: NIH 3T3 Cells; Animals; Mice; Water; Chitosan; Biocompatible Materials; Solutions; Spectrum Analysis; Temperature; Cell Survival; Hydrogen-Ion Concentration; Solubility; Viscosity
Rights: © Koninklijke Brill NV, Leiden, 2009
RMID: 0020112522
DOI: 10.1163/156856209X444385
Appears in Collections:Chemical Engineering publications

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