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|Title:||Oscillation of mitogen-activated protein kinases in response to endoplasmic reticulum stress|
|Citation:||Analytical Biochemistry, 2011; 417(2):292-294|
|Publisher:||Academic Press Inc Elsevier Science|
|Hui Zhang, Yang Zhao, Tian Tian, Adrienne W. Paton, James C. Paton, Masanori Kitamura|
|Abstract:||Periodic patterns of biochemical systems determine the function, behavior, and fate of eukaryotic cells. The cascades of mitogen-activated protein (MAP) kinases play crucial roles in a diverse range of cell function, and recent reports indicate that oscillation of extracellular signal-regulated kinase (ERK) activity is observed following stimulation by some growth factors. In the current report, we provide evidence that ERK and c-Jun N-terminal kinase, but not p38 MAP kinase, are activated periodically in response to endoplasmic reticulum stress. When activity of MAP kinases is evaluated, their oscillatory property should be considered carefully, especially under stress conditions.|
|Keywords:||MAP kinase; ERK; JNK; Subtilase cytotoxin; ER stress; Oscillation|
|Rights:||Copyright © 2011 Elsevier Inc. All rights reserved.|
|Appears in Collections:||Molecular and Biomedical Science publications|
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