Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/68929
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Type: Journal article
Title: Oscillation of mitogen-activated protein kinases in response to endoplasmic reticulum stress
Author: Zhang, H.
Zhao, Y.
Tian, T.
Paton, A.
Paton, J.
Kitamura, M.
Citation: Analytical Biochemistry, 2011; 417(2):292-294
Publisher: Academic Press Inc Elsevier Science
Issue Date: 2011
ISSN: 0003-2697
1096-0309
Statement of
Responsibility: 
Hui Zhang, Yang Zhao, Tian Tian, Adrienne W. Paton, James C. Paton, Masanori Kitamura
Abstract: Periodic patterns of biochemical systems determine the function, behavior, and fate of eukaryotic cells. The cascades of mitogen-activated protein (MAP) kinases play crucial roles in a diverse range of cell function, and recent reports indicate that oscillation of extracellular signal-regulated kinase (ERK) activity is observed following stimulation by some growth factors. In the current report, we provide evidence that ERK and c-Jun N-terminal kinase, but not p38 MAP kinase, are activated periodically in response to endoplasmic reticulum stress. When activity of MAP kinases is evaluated, their oscillatory property should be considered carefully, especially under stress conditions.
Keywords: MAP kinase; ERK; JNK; Subtilase cytotoxin; ER stress; Oscillation
Rights: Copyright © 2011 Elsevier Inc. All rights reserved.
RMID: 0020111964
DOI: 10.1016/j.ab.2011.06.025
Appears in Collections:Molecular and Biomedical Science publications

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