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https://hdl.handle.net/2440/69139
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dc.contributor.author | Harvey, B. | - |
dc.contributor.author | Musgrave, I. | - |
dc.contributor.author | Ohlsson, K. | - |
dc.contributor.author | Fransson, A. | - |
dc.contributor.author | Smid, S. | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Food Chemistry, 2011; 129(4):1729-1736 | - |
dc.identifier.issn | 0308-8146 | - |
dc.identifier.issn | 1873-7072 | - |
dc.identifier.uri | http://hdl.handle.net/2440/69139 | - |
dc.description.abstract | Alzheimer’s disease is associated with amyloid-β plaques eliciting neuronal oxidative stress. Many naturally occurring compounds have antioxidant properties, but it is unclear if this alone protects against amyloid-β exposure. This study investigated the protective effects of selected bioactive compounds against amyloid-β and pro-oxidant-evoked neurotoxicity in PC12 cells. Neither resveratrol, (−)-epigallocatechin-3-gallate, cyanidin rutinoside or grape skin extract protected PC12 cells against H2O2 or tert butyl hydroperoxide toxicity. Amyloid-β resulted in a concentration-dependent reduction in PC12 cell viability that was unaffected by resveratrol or cyanidin rutinoside pre-treatment. By contrast, (−)-epigallocatechin-3-gallate and grape skin extract significantly reduced amyloid-β-evoked neurotoxicity (by 40%). Only (−)-epigallocatechin-3-gallate was directly able to inhibit amyloid-β aggregate and fibril formation. These results suggest that (−)-epigallocatechin-3-gallate protects neuronal cells by disrupting amyloid-β fibril formation; bioactive polyphenols which disrupt fibril aggregation may confer additional neuroprotection when compared against antioxidant activity alone. | - |
dc.description.statementofresponsibility | B.S. Harvey, I.F. Musgrave, K.S. Ohlsson, Å. Fransson, S.D. Smid | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Sci Ltd | - |
dc.rights | Crown copyright © 2011 Published by Elsevier Ltd. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.foodchem.2011.06.040 | - |
dc.subject | Amyloid-β | - |
dc.subject | Cyanidin rutinoside | - |
dc.subject | (−)-Epigallocatechin-3-gallate | - |
dc.subject | Grape skin extract | - |
dc.subject | Oxidative stress | - |
dc.subject | Polyphenols | - |
dc.subject | Resveratrol | - |
dc.title | The green tea polyphenol (−)-epigallocatechin-3-gallate inhibits amyloid-β evoked fibril formation and neuronal cell death in vitro | - |
dc.title.alternative | The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits amyloid-beta evoked fibril formation and neuronal cell death in vitro | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.foodchem.2011.06.040 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Musgrave, I. [0000-0003-1016-0588] | - |
dc.identifier.orcid | Smid, S. [0000-0003-4192-7219] | - |
Appears in Collections: | Aurora harvest 5 Pharmacology publications |
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