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Type: Journal article
Title: Biomimetic three-dimensional microenvironment for controlling stem cell fate
Author: Zhang, H.
Dai, S.
Bi, J.
Liu, K.
Citation: Interface Focus, 2011; 1(5):792-803
Publisher: The Royal Society Publishing
Issue Date: 2011
ISSN: 2042-8898
Statement of
Hu Zhang, Sheng Dai, Jingxiu Bi and Kuo-Kang Liu
Abstract: Stem cell therapy is an emerging technique which is being translated into treatment of degenerated tissues. However, the success of translation relies on the stem cell lineage commitment in the degenerated regions of interest. This commitment is precisely controlled by the stem cell microenvironment. Engineering a biomimetic three-dimensional microenvironment enables a thorough understanding of the mechanisms of governing stem cell fate. We review the individual microenvironment components, including soluble factors, extracellular matrix, cell–cell interaction and mechanical stimulation. The perspectives in creating the biomimetic microenvironments are discussed with emerging techniques.
Keywords: stem cell; microenvironment; stem cell niche; microscale technologies; bioprinting; optical tweezers
Rights: This journal is copyright 2011 The Royal Society
RMID: 0020115136
DOI: 10.1098/rsfs.2011.0035
Appears in Collections:Chemical Engineering publications

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