Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Biomimetic three-dimensional microenvironment for controlling stem cell fate|
|Citation:||Interface Focus, 2011; 1(5):792-803|
|Publisher:||The Royal Society Publishing|
|Hu Zhang, Sheng Dai, Jingxiu Bi and Kuo-Kang Liu|
|Abstract:||Stem cell therapy is an emerging technique which is being translated into treatment of degenerated tissues. However, the success of translation relies on the stem cell lineage commitment in the degenerated regions of interest. This commitment is precisely controlled by the stem cell microenvironment. Engineering a biomimetic three-dimensional microenvironment enables a thorough understanding of the mechanisms of governing stem cell fate. We review the individual microenvironment components, including soluble factors, extracellular matrix, cell–cell interaction and mechanical stimulation. The perspectives in creating the biomimetic microenvironments are discussed with emerging techniques.|
|Keywords:||stem cell; microenvironment; stem cell niche; microscale technologies; bioprinting; optical tweezers|
|Rights:||This journal is copyright 2011 The Royal Society|
|Appears in Collections:||Chemical Engineering publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.