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|Title:||Muscle and adipose tissue biopsy in older adults with type 2 diabetes|
|Citation:||Journal of Diabetes Mellitus, 2011; 1(3):27-35|
|Publisher:||Scientific Research Publishing Inc|
|Yi Wang, David Simar, Kylie Anderberg, Yorgi Mavros, Shelley Kay, Renru Zhao, Bernhard T. Baune, Anthony O’Sullivan, Nalin Singh, Maria Fiatarone Singh|
|Abstract:||We describe a method for obtaining skeletal muscle and subcutaneous adipose tissue in a single percutaneous needle biopsy procedure. Biopsies were performed in a double-blind randomized, sham-exercise controlled clinical trial of power training in 103 older adults with type 2 diabetes. In total 110 biopsies (73.3%) were performed in the first 50 participants at 3 time points. Muscle samples were obtained in 102/110 biopsies (92.7%); adipose samples were obtained in 72/110 biopsies (65.5%); both tissue types were obtained in 65/110 biopsies (59.1%). The average weight of muscle samples was 131±92 mg and the median weight of adipose samples was 51 mg (range 3 to 412 mg). No adverse effects of biopsies were reported other than mild transient pain or light-headedness. This is one of the first reports of both adipose and muscle tissue obtained during the same biopsy, and the first to describe in detail sampling technique, yield and safety.|
|Keywords:||Biopsy; Skeletal Muscle; Subcutaneous Adipose Tissue; Type 2 Diabetes|
|Rights:||Copyright © 2011 SciRes.|
|Appears in Collections:||Psychiatry publications|
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