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https://hdl.handle.net/2440/6955
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Type: | Journal article |
Title: | Familial partial epilepsy with variable foci: A new partial epilepsy syndrome with suggestion of linkage to chromosome 2 |
Author: | Scheffer, I. Phillips, H. O'Brien, C. Saling, M. Wrennall, J. Wallace, R. Mulley, J. Berkovic, S. |
Citation: | Annals of Neurology, 1998; 44(6):890-899 |
Publisher: | Wiley |
Issue Date: | 1998 |
ISSN: | 0364-5134 1531-8249 |
Statement of Responsibility: | Dr. Ingrid E. Scheffer, Hilary A. Phillips, Catherine E. O'Brien, Michael M. Saling, Jacqueline A. Wrennall, Robyn H. Wallace, John C. Mulley, Samuel F. Berkovic |
Abstract: | Familial partial epilepsy with variable foci (FPEVF) joins the recently recognized group of inherited partial epilepsies. We describe an Australian family with 10 individuals with partial seizures over four generations. Detailed electroclinical studies were performed on all affected and 17 clinically unaffected family members. The striking finding was that the clinical features of the seizures and interictal electroencephalographic foci differed among family members and included frontal, temporal, occipital, and centroparietal seizures. Mean age of seizure onset was 13 years (range, 0.75-43 years). Two individuals without seizures had epileptiform abnormalities on electroencephalographic studies. Penetrance of seizures was 62%. A genome-wide search failed to demonstrate definitive linkage, but a suggestion of linkage was found on chromosome 2q with a LOD score of 2.74 at recombination fraction of zero with the marker D2S133. FPEVF differs from the other inherited partial epilepsies where partial seizures in different family members are clinically similar. The inherited nature of this new syndrome may be overlooked because of relatively low penetrance and because of the variability in age at onset and electroclinical features between affected family members. |
Keywords: | Chromosomes, Human, Pair 2 Humans Epilepsies, Partial Syndrome Genetic Markers Tomography, X-Ray Computed Electroencephalography Pedigree Neuropsychological Tests Lod Score Adult Middle Aged Child Child, Preschool Female Male Genetic Linkage |
Rights: | Copyright © 1998 by the American Neurological Association |
DOI: | 10.1002/ana.410440607 |
Published version: | http://dx.doi.org/10.1002/ana.410440607 |
Appears in Collections: | Aurora harvest Paediatrics publications |
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