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Type: Journal article
Title: Animal models of mucositis: Implications for therapy
Author: Bowen, J.
Gibson, R.
Keefe, D.
Citation: The Journal of Supportive Oncology, 2011; 9(5):161-168
Publisher: Elsevier Oncology
Issue Date: 2011
ISSN: 1544-6794
Statement of
Joanne M. Bowen, Rachel J. Gibson and Dorothy M. K. Keefe
Abstract: Alimentary mucositis is a major acute complication in the clinical setting, occurring in a large percentage of patients undergoing cytotoxic therapy. One of the major problems with alimentary mucositis is that the underlying mechanisms behind its development are not entirely understood, which makes it extremely difficult to develop effective interventions. Animal models provide a critical source of knowledge when sampling from patients is unavailable or interventions are yet to be fully tested. This review focuses on the animal models used to increase our understanding of the mechanisms of mucositis and translate new antimucotoxic agents into clinical trials.
Keywords: Intestinal Mucosa; Gastric Mucosa; Mouth Mucosa; Animals; Humans; Disease Models, Animal; Antineoplastic Agents; Radiotherapy; Mucositis
Rights: Copyright © 2011 Elsevier Inc. All rights reserved.
RMID: 0020115316
DOI: 10.1016/j.suponc.2011.04.009
Appears in Collections:Physiology publications

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