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https://hdl.handle.net/2440/70615
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Type: | Journal article |
Title: | The impact of obesity on oocytes: evidence for lipotoxicity mechanisms |
Author: | Linyan Wu, L. Norman, R. Robker, R. |
Citation: | Reproduction Fertility and Development, 2012; 24(1):29-34 |
Publisher: | C S I R O Publishing |
Issue Date: | 2012 |
ISSN: | 1031-3613 1448-5990 |
Statement of Responsibility: | Linda L.-Y. Wu, Robert J. Norman and Rebecca L. Robker |
Abstract: | Obesity can have detrimental effects on pregnancy rates in natural conceptions and also in women undergoing IVF or intracytoplasmic sperm injection (ICSI). This review summarises the most recent clinical literature investigating whether obesity impacts oocyte quality and early embryo growth. In other tissues, obesity leads to lipotoxicity responses including endoplasmic reticulum stress, mitochondrial dysfunction and apoptosis. Recent reports indicate that lipotoxicity is a mechanism by which obesity may impact oocyte quality. |
Keywords: | Endoplasmic reticulum stress palmitate |
Rights: | © CSIRO 2012 |
DOI: | 10.1071/RD11904 |
Published version: | http://dx.doi.org/10.1071/rd11904 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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