Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/71181
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Type: Journal article
Title: The role of n-3 LCPUFA in pregnancy
Author: Makrides, M.
Citation: Oleagineux Corps Gras Lipides, 2011; 18(5):255-258
Publisher: John Libbey Eurotext Ltd
Issue Date: 2011
ISSN: 1258-8210
1950-697X
Statement of
Responsibility: 
Maria Makrides
Abstract: The metabolic demand for n-3 long chain polyunsaturated fatty acids (n-3 LCPUFA), particularly docosahexaenoic acid (22: 6 n-3, DHA) is increased during pregnancy because of the extra needs of the fetus, expanded maternal cell mass and placenta. However, in Western countries maternal dietary n-3 LCPUFA intake in pregnancy is low and it is not clear whether adaptive metabolic mechanisms, such as increased DHA synthesis from precursor fatty acids, are capable of meeting the increased need in pregnancy. Consequently randomized controlled trials have been important to determine whether additional dietary n-3 LCPUFA in pregnancy modifies pregnancy, maternal and infant health outcomes. Supplementation with at least 1g n-3 LCPUFA per day results in a modest increase in the duration of gestation that may be most evident at the extremes of gestation. Additionally, n-3 LPUFA supplementation of well nourished pregnant women has little benefit in preventing maternal postnatal depression and is unlikely to result in major benefits to the developmental outcomes of young children. Further work in needed to identify the specific ''at risk'' groups who are most likely to benefit from supplementation.
Keywords: DHA
pregnancy
pregnancy outcomes
maternal depression
infant development
Rights: Copyright John Libbey Eurotext Ltd.
DOI: 10.1684/ocl.2011.0408
Published version: http://www.jle.com/en/revues/agro_biotech/ocl/e-docs/00/04/6E/6A/article.phtml
Appears in Collections:Aurora harvest 5
Paediatrics publications

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