Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/71245
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dc.contributor.authorFurness, D.en
dc.contributor.authorYasin, N.en
dc.contributor.authorDekker, G.en
dc.contributor.authorThompson, S.en
dc.contributor.authorRoberts, C.en
dc.date.issued2012en
dc.identifier.citationThe Journal of Maternal - Fetal & Neonatal Medicine, 2012; 25(8):1423-1427en
dc.identifier.issn1476-7058en
dc.identifier.issn1476-4954en
dc.identifier.urihttp://hdl.handle.net/2440/71245-
dc.description.abstractObjective: To determine if maternal circulating red blood cell (RBC) folate concentration in early pregnancy is associated with late gestation pregnancy complications including small for gestational age (SGA) infants, preeclampsia and preterm birth (PTB) in a socioeconomically disadvantaged population. Method: This was a retrospective case control study, conducted at Lyell McEwin Health Service, South Australia, including 400 primiparous women. RBC folate and demographic data were collected at 10–12 weeks gestation. Pregnancy outcome data were obtained from patient case notes. Results: Patients who were folate deficient were more likely to develop pregnancy complications, specifically SGA (OR 6.9, 95% CI 2–24.3) and PTB (OR 5.4 95% CI 1.4–21.2). Those who were folate insufficient were also at increased risk of SGA (OR 3.0, 95% CI 1.3–7.7). No association between folate and preeclampsia was found. Women who were supplementing with folic acid delivered infants who were 179 g heavier (5.5% increased birth weight, P = 0.003) and 4.5 days later, compared to those who did not supplement. Furthermore, low RBC folate was associated with cigarette smoking (P < 0.001). Conclusions: Maternal RBC folate concentration in early pregnancy is associated with SGA and PTB, but not with preeclampsia.en
dc.description.statementofresponsibilityDenise L.F. Furness, Nooraishah Yasin, Gustaaf A. Dekker, Steven D. Thompson & Claire T. Robertsen
dc.language.isoenen
dc.publisherTaylor & Francis Ltden
dc.rightsCopyright © 2011 Informa UK, Ltd.en
dc.subjectFolic acid; pregnancy; preeclampsia; preterm birth; red blood cell folate; SGAen
dc.titleMaternal red blood cell folate concentration at 10-12 weeks gestation and pregnancy outcomeen
dc.typeJournal articleen
dc.identifier.rmid0020118581en
dc.identifier.doi10.3109/14767058.2011.636463en
dc.identifier.pubid24786-
pubs.library.collectionObstetrics and Gynaecology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidRoberts, C. [0000-0002-9250-2192]en
Appears in Collections:Obstetrics and Gynaecology publications

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