Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/71319
Type: | Conference paper |
Title: | Relation between QT interval variability and cardiac sympathetic innervation in patients with diabetes mellitus |
Author: | Baumert, M. Sacre, J. Franjic, B. |
Citation: | Computing in Cardiology, 2011; 38:57-60 |
Publisher: | Computing in Cardiology |
Publisher Place: | online |
Issue Date: | 2011 |
Series/Report no.: | Computing in Cardiology Conference |
ISBN: | 9781457706127 |
ISSN: | 2325-8861 2325-887X |
Conference Name: | Computing in Cardiology (2011 : Hangzhou, China) |
Editor: | Murray, A. |
Statement of Responsibility: | Mathias Baumert, Julian Sacre and Bennett Franjic |
Abstract: | Elevated QT interval variability (QTV) has been asso- ciated with increased cardiac mortality, but the underlying mechanisms are incompletely understood. Sympathetic ac- tivity is thought to be a main contributor to QTV. The aim of this study was to investigate the relation between car- diac sympathetic integrity and QTV in 15 patients with type 2 diabetes mellitus and varying degrees of cardiac autonomic neuropathy. Cardiac sympathetic innervation was assessed by 123I-mIBG scintigraphy based on heart- to-mediastinum ratio of 123I-mIBG uptake 4 hours after infusion. To assess QTV high resolution ECGs (1000 Hz) were recorded during standing. Beat-to-beat QT inter- vals were calculated over a period of 5 minutes, using a template-stretching algorithm. QTV was quantified using time and frequency domain measures as well as non-linear approaches (symbolic dynamics, fractal dimension). The group mean and standard deviation of HMR values were 1.07 ± 0.48. Time and frequency domain QTV parame- ters were significantly increased in subjects with sympa- thetic dysinnervation and inversely correlated with HMR (r = −0.7, p < 0.001). In conclusion, there is a clear link between sympathetic dysinnervation and elevated QTV in patients with type 2 diabetes mellitus during sympathetic activation. Sympathetic dysinnervation is associated with increased ventricular repolarization lability. |
Description: | Computing in Cardiology 2011, 18-21 September 2011, Zhejiang University, Hangzhou, China |
Rights: | Articles in this volume are copyright (C) 2011 by their respective authors, and are licensed by their authors under the Creative Commons Attribution License 2.5 (CCAL). |
Grant ID: | http://purl.org/au-research/grants/arc/DP110102049 |
Description (link): | http://www.cinc.org/archives/2011/ |
Appears in Collections: | Aurora harvest 5 Electrical and Electronic Engineering publications |
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File | Description | Size | Format | |
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hdl_71319.pdf | Published version | 115.01 kB | Adobe PDF | View/Open |
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