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Type: Journal article
Title: The molecular basis of fragile sites in human chromosomes
Author: Sutherland, G.
Richards, R.
Citation: Current Opinion in Genetics and Development, 1995; 5(3):323-327
Publisher: Current Biology Ltd.
Issue Date: 1995
ISSN: 0959-437X
Statement of
Grant R. Sutherland and Robert I. Richards
Abstract: Fragile sites on chromosomes have been classified into a number of groups according to their frequency and the conditions required to induce them. A number of the rare folate-sensitive fragile sites have been characterized and shown to be amplified methylated CCG trinucleotide repeats. One common fragile site has been partly characterized and appears to be a region of fragility, rather than a single site.
Keywords: Chromosomes, Human; Humans; Chromosome Fragility; Aphidicolin; Culture Techniques; Sequence Analysis, DNA; Gene Expression Regulation; Repetitive Sequences, Nucleic Acid; Mutation; Genes; Chromosome Fragile Sites
RMID: 0030005682
DOI: 10.1016/0959-437X(95)80046-8
Appears in Collections:Paediatrics publications

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