Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/71805
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Type: Journal article
Title: Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1
Author: Robinson, J.
MacArthur, S.
Ross-Innes, C.
Tilley, W.
Neal, D.
Mills, I.
Carroll, J.
Citation: The EMBO Journal, 2011; 30(15):3019-3027
Publisher: Nature Publishing Group
Issue Date: 2011
ISSN: 0261-4189
1460-2075
Statement of
Responsibility: 
Jessica LL Robinson, Stewart MacArthur, Caryn S Ross-Innes, Wayne D Tilley, David E Neal, Ian G Mills, and Jason S Carroll
Abstract: Breast cancer is a heterogeneous disease and several distinct subtypes exist based on differential gene expression patterns. Molecular apocrine tumours were recently identified as an additional subgroup, characterised as oestrogen receptor negative and androgen receptor positive (ER− AR+), but with an expression profile resembling ER+ luminal breast cancer. One possible explanation for the apparent incongruity is that ER gene expression programmes could be recapitulated by AR. Using a cell line model of ER− AR+ molecular apocrine tumours (termed MDA-MB-453 cells), we map global AR binding events and find a binding profile that is similar to ER binding in breast cancer cells. We find that AR binding is a near-perfect subset of FoxA1 binding regions, a level of concordance never previously seen with a nuclear receptor. AR functionality is dependent on FoxA1, since silencing of FoxA1 inhibits AR binding, expression of the majority of the molecular apocrine gene signature and growth cell growth. These findings show that AR binds and regulates ER cis-regulatory elements in molecular apocrine tumours, resulting in a transcriptional programme reminiscent of ER-mediated transcription in luminal breast cancers.
Keywords: androgen receptor
breast cancer
chromatin
FoxA1
molecular apocrine
Rights: © 2011 European Molecular Biology Organization
DOI: 10.1038/emboj.2011.216
Published version: http://dx.doi.org/10.1038/emboj.2011.216
Appears in Collections:Aurora harvest
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