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https://hdl.handle.net/2440/7181
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Type: | Journal article |
Title: | Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes |
Author: | Honeyman, B. Coulson, B. Stone, N. Gellert, S. Goldwater, P. Steele, C. Couper, J. Tait, B. Coleman, P. Harrison, L. |
Citation: | Diabetes, 2000; 49(8):1319-1324 |
Publisher: | Amer Diabetes Assoc |
Issue Date: | 2000 |
ISSN: | 0012-1797 1939-327X |
Abstract: | Pancreatic islet autoimmunity leading to type 1 diabetes could be triggered by viruses in genetically susceptible individuals. Rotavirus (RV), the most common cause of childhood gastroenteritis, contains peptide sequences highly similar to T-cell epitopes in the islet autoantigens GAD and tyrosine phosphatase IA-2 (IA-2), suggesting T-cells to RV could trigger islet autoimmunity by molecular mimicry. We therefore sought an association between RV infection and islet autoantibody markers in children at risk for diabetes who were followed from birth. There was a specific and highly significant association between RV seroconversion and increases in any of these antibodies: 86% of antibodies to IA-2, 62% to insulin, and 50% to GAD first appeared or increased with increases in RV IgG or IgA. RV infection may therefore trigger or exacerbate islet autoimmunity in genetically susceptible children. |
Keywords: | Islets of Langerhans Humans Rotavirus Rotavirus Infections Gastroenteritis Diabetes Mellitus, Type 1 Glutamate Decarboxylase Membrane Proteins Autoantibodies Insulin Antibodies Antigens, Viral Autoantigens Odds Ratio Risk Factors Longitudinal Studies Autoimmunity Molecular Mimicry Infant, Newborn Australia Protein Tyrosine Phosphatases Protein Tyrosine Phosphatase, Non-Receptor Type 1 Receptor-Like Protein Tyrosine Phosphatases, Class 8 |
DOI: | 10.2337/diabetes.49.8.1319 |
Published version: | http://dx.doi.org/10.2337/diabetes.49.8.1319 |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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