Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/72379
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Type: Journal article
Title: Dietary omega-3 supplementation exacerbates left ventricular dysfunction in an ovine model of anthracycline-induced cardiotoxicity
Author: Carbone, A.
Psaltis, P.
Nelson, A.
Metcalf, R.
Richardson, J.
Weightman, M.
Thomas, A.
Finnie, J.
Young, G.
Worthley, S.
Citation: Journal of Cardiac Failure, 2012; 18(6):502-511
Publisher: Churchill Livingstone Inc Medical Publishers
Issue Date: 2012
ISSN: 1071-9164
1532-8414
Statement of
Responsibility: 
Angelo Carbone, Peter J. Psaltis, Adam J. Nelson, Robert Metcalf, James D. Richardson, Michael Weightman, Anthony Thomas, John W. Finnie, Glenn D. Young and Stephen G. Worthley
Abstract: BACKGROUND: Cumulative dose-dependent nonischemic cardiomyopathy (NICM) remains a significant risk with the use of some chemotherapeutic agents. In this context, omega-3 polyunsaturated fatty acids (PUFA) have been investigated for their cardioprotective potential in rodent and in vitro models of anthracycline toxicity, with conflicting results. This study evaluated prophylactic omega-3 PUFA supplementation in a large-animal model of anthracycline-induced NICM. METHODS AND RESULTS: Merino sheep were randomized to oral drenching with omega-3 PUFA (fish oil; n 5 8) or olive oil placebo (n 5 9) 3 weeks before commencing repeated intracoronary infusions of doxorubicin (DOX) to induce cardiac dysfunction. Cumulative DOX dose was 3.6 mg/kg. Drenching was continued for 12 weeks after final DOX exposure. Despite significant increases in tissue omega-3 PUFA levels (P < .05 vs placebo), omega-3etreated sheep displayed greater signs of anthracycline cardiotoxicity than placebo animals, consisting of left ventricular dilatation and a greater decline in ejection fraction (P < .05), although myocardial fibrosis burden was similar in both groups. CONCLUSIONS: Dietary intake of omega-3 PUFA fails to prevent and may indeed exacerbate DOX-induced cardiotoxicity. Clinical use of omega-3 supplementation during chemotherapy should be deferred until more information is available regarding the mechanisms of interaction between fatty acids and the myocardium during anthracycline exposure.
Keywords: Animal models; cardiomyopathy; doxorubicin, fish oil
Rights: © 2012 Published by Elsevier Inc.
RMID: 0020119400
DOI: 10.1016/j.cardfail.2012.03.005
Appears in Collections:Medicine publications

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