Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/72416
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dc.contributor.authorAndraweera, P.en
dc.contributor.authorDekker, G.en
dc.contributor.authorLaurence, J.en
dc.contributor.authorRoberts, C.en
dc.date.issued2012en
dc.identifier.citationPlacenta, 2012; 33(6):467-472en
dc.identifier.issn0143-4004en
dc.identifier.issn1532-3102en
dc.identifier.urihttp://hdl.handle.net/2440/72416-
dc.description.abstractThe pregnancy complications preeclampsia, gestational hypertension, small for gestational age infants (SGA) and pre-term birth (PTB) affect approximately 21% of all pregnancies. The Vascular Endothelial Growth Factor family (VEGF) is implicated in the pathogenesis of these complications. We aimed to evaluate the placental mRNA expression of VEGFA, PGF, FLT1 and KDR in pregnancies complicated by preeclampsia, gestational hypertension, SGA infants and pre-term birth.Placentae were collected at delivery from women with pregnancies complicated by preeclampsia (n = 18), gestational hypertension (n = 15), normotensive SGA infants (n = 13), late spontaneous pre-term birth (n = 10) and uncomplicated pregnancy (n = 30). RNA was extracted and VEGFA, PGF, FLT1 and KDR expression were quantified using qRT-PCR. Kruskal Wallis test was used to compare placental mRNA expression in the adverse pregnancy outcome groups compared to uncomplicated term pregnancy.Compared to placental mRNA from uncomplicated pregnancies, VEGFA (p = 0.006), PGF (p < 0.001), KDR (p < 0.001) and FLT1 (p = 0.02) mRNA were reduced in preeclamptic placentae; VEGFA (p < 0.001), PGF (p = 0.01) and KDR (p = 0.008) mRNA were reduced in placentae from pregnancies complicated by gestational hypertension; VEGFA (p = 0.03) mRNA was reduced in normotensive SGA pregnancies; VEGFA (p = 0.008), PGF (p = 0.01), KDR (p = 0.04) and FLT1 (p = 0.02) mRNA were reduced in placentae from late PTB.VEGF family of angiogenic growth factor mRNA expression in the placenta is reduced in gestational hypertensive disorders, SGA and in pre-term birth.en
dc.description.statementofresponsibilityP.H. Andraweera, G.A. Dekker, J.A. Laurence and C.T. Robertsen
dc.language.isoenen
dc.publisherW B Saunders Co Ltden
dc.rights© 2012 Elsevier Ltd. All rights reserveden
dc.subjectPlacenta; Humans; Hypertension, Pregnancy-Induced; Pre-Eclampsia; Premature Birth; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factor A; Pregnancy Proteins; RNA, Messenger; Pregnancy Outcome; Case-Control Studies; Pregnancy; Adult; Infant, Newborn; Infant, Small for Gestational Age; Female; Placenta Growth Factoren
dc.titlePlacental expression of VEGF family mRNA in adverse pregnancy outcomesen
dc.typeJournal articleen
dc.identifier.rmid0020118954en
dc.identifier.doi10.1016/j.placenta.2012.02.013en
dc.identifier.pubid24595-
pubs.library.collectionObstetrics and Gynaecology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidDekker, G. [0000-0002-7362-6683]en
dc.identifier.orcidRoberts, C. [0000-0002-9250-2192]en
Appears in Collections:Obstetrics and Gynaecology publications

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