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Type: Journal article
Title: AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location
Author: Stapleton, D.
Woollatt, E.
Mitchelhill, K.
Nicholl, J.
Fernandez, C.
Michell, B.
Witters, L.
Power, D.
Sutherland, G.
Kemp, B.
Citation: FEBS Letters, 1997; 409(3):452-456
Issue Date: 1997
ISSN: 0014-5793
Statement of
Stapleton, David; Woollatt, Erica; Mitchelhill, Ken I; Nicholl, Jillian K; Fernandez, C.Shamala; Michell, Belinda J; Witters, Lee A; Power, David A; Sutherland, Grant R; Kemp, Bruce E
Abstract: The AMP-activated protein kinase (AMPK) consists of catalytic alpha and non-catalytic, beta and gamma (38 kDa) subunits and is responsible for acting as a metabolic sensor for AMP levels. There are multiple genes for each subunit and we find that rat liver AMPK-alpha2 isoform catalytic subunit is associated with beta1 and gamma1 and not with beta2 or gamma2 subunit isoforms. The beta1 and gamma1 isoforms are also subunits of the alpha1 isoform. The sequence of cloned human AMPK-beta1 is 95% identical in amino acid sequence with rat beta1. Human chromosomal localizations were determined for AMPK-alpha1 (5p11-p14), AMPK-beta1 (12q24.1-24.3) and AMPK-gamma1 (12q12-q14), respectively.
Keywords: Liver; Chromosomes, Human, Pair 5; Chromosomes, Human, Pair 7; Chromosomes, Human, Pair 12; Animals; Humans; Rats; Multienzyme Complexes; Isoenzymes; Protein Kinases; Protein-Serine-Threonine Kinases; Chromosome Mapping; Metaphase; Amino Acid Sequence; Multigene Family; Molecular Sequence Data; Male; AMP-Activated Protein Kinases
RMID: 0030005651
DOI: 10.1016/S0014-5793(97)00569-3
Appears in Collections:Paediatrics publications

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