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https://hdl.handle.net/2440/7245
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Type: | Journal article |
Title: | Substrate specificity of rat liver mitochondrial carnitine palmitoyl transferase I : Evidence against a-oxidation of phytanic acid in rat liver mitochondria |
Author: | Singh, H. Poulos, A. |
Citation: | FEBS Letters, 1995; 359(2-3):179-183 |
Publisher: | Elsevier |
Issue Date: | 1995 |
ISSN: | 0014-5793 1873-3468 |
Abstract: | The two branched chain fatty acids pristanic acid (2,6,10,14-tetramethylpentadecanoic acid) and phytanic acid (3,7,11,15-tetramethylhexadecanoic acid) were converted to co-enzyme A thioesters by rat liver mitochondrial outer membranes. However, these branched chain fatty acids could not be converted to pristanoyl and phytanoyl carnitines, respectively, by mitochondrial outer membranes. As expected, the unbranched long chain fatty acids, stearic acid and palmitic acid, were rapidly converted to stearoyl and palmitoyl carnitines, respectively, by mitochondrial outer membranes. These observations indicate that the branched chain fatty acids could not be transported into mitochondria. The data presented strongly suggest that in rat liver, alpha-oxidation of phytanic acid occurs in organelles other than mitochondria. |
Keywords: | Intracellular Membranes Mitochondria, Liver Animals Rats Phytanic Acid Coenzyme A Coenzyme A Ligases Carnitine O-Palmitoyltransferase Fatty Acids Saccharomyces cerevisiae Proteins Repressor Proteins Substrate Specificity Biological Transport Oxidation-Reduction In Vitro Techniques |
DOI: | 10.1016/0014-5793(95)00035-8 |
Published version: | http://dx.doi.org/10.1016/0014-5793(95)00035-8 |
Appears in Collections: | Aurora harvest Paediatrics publications |
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