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https://hdl.handle.net/2440/7247
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Type: | Journal article |
Title: | Influence of antenatal ultrasound on the management of fetal exomphalos |
Author: | Holland, A. Ford, W. Linke, R. Furness, M. Hayward, C. |
Citation: | Fetal Diagnosis and Therapy: clinical advances and basic research, 1999; 14(4):223-228 |
Publisher: | S. Karger AG |
Issue Date: | 1999 |
ISSN: | 1015-3837 1421-9964 |
Abstract: | <h4>Objective</h4>To determine the influence of antenatal ultrasound on the management of exomphalos.<h4>Methods</h4>Retrospective case note review of 23 fetuses and infants referred to our institution with either a pre- or postnatal diagnosis of exomphalos over a 7-year period.<h4>Results</h4>There were 21 cases of exomphalos of which 18 were correctly diagnosed on antenatal ultrasound by 18 weeks' gestation. There were 2 false-positives and 3 false-negatives, including 1 case of amniotic band syndrome with an abdominal wall defect and 1 morphologically normal fetus. Associated anomalies were correctly identified in 12 but incorrectly reported in 8. Maternal serum alpha-fetoprotein levels were abnormal in 61% of cases of abdominal wall defects in this series. Amniocentesis was performed in 12 and cordocentesis in 1. There were 13 terminations, including 2 trisomy 18s and 1 trisomy 13. Two fetal deaths followed amniocentesis. Of the 10 live births, 9 had their exomphalos repaired with a 1-year survival rate of 89%. Prenatal diagnosis did not appear to influence outcome.<h4>Conclusions</h4>Antenatal ultrasound diagnosed 86% of cases of exomphalos and correctly reported 67% of associated anomalies. Amniocentesis may have led to the death of 1 morphologically normal fetus. |
Keywords: | Humans Hernia, Umbilical alpha-Fetoproteins Diagnostic Errors Ultrasonography, Prenatal Amniocentesis Prognosis Abortion, Eugenic Retrospective Studies Pregnancy Adolescent Adult Infant, Newborn Female |
DOI: | 10.1159/000020926 |
Published version: | http://dx.doi.org/10.1159/000020926 |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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