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https://hdl.handle.net/2440/72638
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Type: | Journal article |
Title: | Further Investigations into the speed of cerebral swelling following blunt cranial trauma |
Author: | Byard, R. Gabrielian, L. Helps, S. Thornton, E. Vink, R. |
Citation: | Journal of Forensic Sciences, 2012; 57(4):973-975 |
Publisher: | Amer Soc Testing Materials |
Issue Date: | 2012 |
ISSN: | 0022-1198 1556-4029 |
Statement of Responsibility: | Roger W. Byard, Levon Gabrielian, Stephen C. Helps, Emma Thornton, and Robert Vink |
Abstract: | An anesthetized sheep model of traumatic brain injury (TBI) has been developed to assess early changes in intracranial pressure (ICP) following closed head injury. Immediately after TBI, a transient (<10 min) hypertensive response occurred, followed by significant and prolonged systemic hypotension. ICP demonstrated a biphasic response, being seven times baseline values of 8 ± 2 mm Hg 10 min after injury, decreasing to 25 ± 2 mm Hg by 30 min, and then increasing to values exceeding 30 mm Hg by 4 h postinjury. ICP was always significantly higher than baseline values, which combined with hypotension, reduced cerebral perfusion pressure to less than 60% of normal. This early and sustained increase in ICP after craniocerebral trauma acutely alters cerebral perfusion pressure and brain oxygenation and provides a potential pathophysiological explanation for immediate clinical manifestations in humans following significant TBI. |
Keywords: | forensic science traumatic brain injury intracranial pressure blunt craniocerebral trauma lucid interval impact shaking |
Rights: | © 2012 American Academy of Forensic Sciences |
DOI: | 10.1111/j.1556-4029.2012.02109.x |
Published version: | http://dx.doi.org/10.1111/j.1556-4029.2012.02109.x |
Appears in Collections: | Aurora harvest 5 Pathology publications |
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