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|Title:||Further Investigations into the speed of cerebral swelling following blunt cranial trauma|
|Citation:||Journal of Forensic Sciences, 2012; 57(4):973-975|
|Publisher:||Amer Soc Testing Materials|
|Roger W. Byard, Levon Gabrielian, Stephen C. Helps, Emma Thornton, and Robert Vink|
|Abstract:||An anesthetized sheep model of traumatic brain injury (TBI) has been developed to assess early changes in intracranial pressure (ICP) following closed head injury. Immediately after TBI, a transient (<10 min) hypertensive response occurred, followed by significant and prolonged systemic hypotension. ICP demonstrated a biphasic response, being seven times baseline values of 8 ± 2 mm Hg 10 min after injury, decreasing to 25 ± 2 mm Hg by 30 min, and then increasing to values exceeding 30 mm Hg by 4 h postinjury. ICP was always significantly higher than baseline values, which combined with hypotension, reduced cerebral perfusion pressure to less than 60% of normal. This early and sustained increase in ICP after craniocerebral trauma acutely alters cerebral perfusion pressure and brain oxygenation and provides a potential pathophysiological explanation for immediate clinical manifestations in humans following significant TBI.|
|Keywords:||forensic science; traumatic brain injury; intracranial pressure; blunt craniocerebral trauma; lucid interval; impact; shaking|
|Rights:||© 2012 American Academy of Forensic Sciences|
|Appears in Collections:||Pathology publications|
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