Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/72638
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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Byard, R. | - |
dc.contributor.author | Gabrielian, L. | - |
dc.contributor.author | Helps, S. | - |
dc.contributor.author | Thornton, E. | - |
dc.contributor.author | Vink, R. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Journal of Forensic Sciences, 2012; 57(4):973-975 | - |
dc.identifier.issn | 0022-1198 | - |
dc.identifier.issn | 1556-4029 | - |
dc.identifier.uri | http://hdl.handle.net/2440/72638 | - |
dc.description.abstract | An anesthetized sheep model of traumatic brain injury (TBI) has been developed to assess early changes in intracranial pressure (ICP) following closed head injury. Immediately after TBI, a transient (<10 min) hypertensive response occurred, followed by significant and prolonged systemic hypotension. ICP demonstrated a biphasic response, being seven times baseline values of 8 ± 2 mm Hg 10 min after injury, decreasing to 25 ± 2 mm Hg by 30 min, and then increasing to values exceeding 30 mm Hg by 4 h postinjury. ICP was always significantly higher than baseline values, which combined with hypotension, reduced cerebral perfusion pressure to less than 60% of normal. This early and sustained increase in ICP after craniocerebral trauma acutely alters cerebral perfusion pressure and brain oxygenation and provides a potential pathophysiological explanation for immediate clinical manifestations in humans following significant TBI. | - |
dc.description.statementofresponsibility | Roger W. Byard, Levon Gabrielian, Stephen C. Helps, Emma Thornton, and Robert Vink | - |
dc.language.iso | en | - |
dc.publisher | Amer Soc Testing Materials | - |
dc.rights | © 2012 American Academy of Forensic Sciences | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1556-4029.2012.02109.x | - |
dc.subject | forensic science | - |
dc.subject | traumatic brain injury | - |
dc.subject | intracranial pressure | - |
dc.subject | blunt craniocerebral trauma | - |
dc.subject | lucid interval | - |
dc.subject | impact | - |
dc.subject | shaking | - |
dc.title | Further Investigations into the speed of cerebral swelling following blunt cranial trauma | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1556-4029.2012.02109.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Byard, R. [0000-0002-0524-5942] | - |
dc.identifier.orcid | Vink, R. [0000-0002-4885-0667] | - |
Appears in Collections: | Aurora harvest 5 Pathology publications |
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